| Round 1 (22) | Round 2 (23) |
| Cagliari - Lens | Anderlecht - Vélez Sársfield |
| Everton - Besiktas | Bastia - Torino |
| FC Utrecht - Udinese | Belenenses - Shakhtar |
| Fiorentina - Anderlecht | Besiktas - Mallorca |
| Hajduk Split - Belenenses | Club Brugge - Olympiakos |
| Mallorca - Yokohama FMarinos | Dinamo - Everton |
| Olympiakos - Dinamo | Leicester City - Fiorentina |
| Sassuolo - Leicester City | Lens - FC Utrecht |
| Shakhtar - Bastia | River Plate - Sassuolo |
| Torino - Club Brugge | Udinese - Cagliari |
| Vélez Sársfield - River Plate | Yokohama FMarinos - Hajduk Split |
|
| Round 3 (24) | Round 4 (25) |
| Cagliari - Anderlecht | Anderlecht - Sassuolo |
| Everton - Club Brugge | Bastia - Mallorca |
| FC Utrecht - Yokohama FMarinos | Belenenses - Vélez Sársfield |
| Fiorentina - Belenenses | Besiktas - Torino |
| Hajduk Split - Leicester City | Club Brugge - Hajduk Split |
| Mallorca - Dinamo | Dinamo - Shakhtar |
| Olympiakos - Bastia | Leicester City - FC Utrecht |
| Sassuolo - Udinese | Lens - Fiorentina |
| Shakhtar - River Plate | River Plate - Everton |
| Torino - Lens | Udinese - Olympiakos |
| Vélez Sársfield - Besiktas | Yokohama FMarinos - Cagliari |
|
| Round 5 (26) | Round 6 (27) |
| Cagliari - Belenenses | Anderlecht - Lens |
| Everton - Lens | Belenenses - River Plate |
| FC Utrecht - River Plate | Club Brugge - Besiktas |
| Fiorentina - Yokohama FMarinos | Dinamo - Bastia |
| Hajduk Split - Besiktas | Everton - Olympiakos |
| Mallorca - Club Brugge | FC Utrecht - Fiorentina |
| Olympiakos - Leicester City | Sassuolo - Cagliari |
| Sassuolo - Bastia | Shakhtar - Hajduk Split |
| Shakhtar - Udinese | Torino - Udinese |
| Torino - Anderlecht | Vélez Sársfield - Mallorca |
| Vélez Sársfield - Dinamo | Yokohama FMarinos - Leicester City |
|
| Round 7 (28) | Round 8 (29) |
| Bastia - Club Brugge | Anderlecht - Besiktas |
| Besiktas - Dinamo | Bastia - Fiorentina |
| Cagliari - FC Utrecht | Cagliari - Mallorca |
| Fiorentina - Sassuolo | Club Brugge - Dinamo |
| Hajduk Split - Everton | FC Utrecht - Sassuolo |
| Leicester City - Torino | Hajduk Split - Vélez Sársfield |
| Lens - Belenenses | Leicester City - River Plate |
| Mallorca - Shakhtar | Lens - Udinese |
| Olympiakos - Vélez Sársfield | Shakhtar - Everton |
| River Plate - Yokohama FMarinos | Torino - Olympiakos |
| Udinese - Anderlecht | Yokohama FMarinos - Belenenses |
|
| Round 9 (30) | Round 10 (31) |
| Belenenses - Leicester City | Anderlecht - Club Brugge |
| Besiktas - Bastia | Belenenses - Olympiakos |
| Dinamo - Anderlecht | Cagliari - Everton |
| Everton - Torino | FC Utrecht - Hajduk Split |
| Fiorentina - Cagliari | Fiorentina - Shakhtar |
| Mallorca - Hajduk Split | Leicester City - Bastia |
| Olympiakos - FC Utrecht | Lens - Dinamo |
| River Plate - Lens | River Plate - Besiktas |
| Sassuolo - Yokohama FMarinos | Sassuolo - Vélez Sársfield |
| Udinese - Club Brugge | Udinese - Mallorca |
| Vélez Sársfield - Shakhtar | Yokohama FMarinos - Torino |
|
| Round 11 (32) | Round 12 (33) |
| Bastia - Lens | Bastia - River Plate |
| Besiktas - Belenenses | Besiktas - Yokohama FMarinos |
| Club Brugge - FC Utrecht | Club Brugge - Cagliari |
| Dinamo - River Plate | Dinamo - Leicester City |
| Everton - Leicester City | Everton - Udinese |
| Hajduk Split - Udinese | Hajduk Split - Lens |
| Mallorca - Sassuolo | Mallorca - Fiorentina |
| Olympiakos - Yokohama FMarinos | Olympiakos - Anderlecht |
| Shakhtar - Anderlecht | Shakhtar - Sassuolo |
| Torino - Cagliari | Torino - Belenenses |
| Vélez Sársfield - Fiorentina | Vélez Sársfield - FC Utrecht |
|
| Round 13 (34) | Round 14 (35) |
| Anderlecht - Hajduk Split | Bastia - Yokohama FMarinos |
| Belenenses - Club Brugge | Besiktas - Cagliari |
| Cagliari - Shakhtar | Club Brugge - River Plate |
| FC Utrecht - Mallorca | Dinamo - Udinese |
| Fiorentina - Torino | Everton - Belenenses |
| Leicester City - Besiktas | Hajduk Split - Fiorentina |
| Lens - Vélez Sársfield | Mallorca - Anderlecht |
| River Plate - Olympiakos | Olympiakos - Sassuolo |
| Sassuolo - Everton | Shakhtar - Lens |
| Udinese - Bastia | Torino - FC Utrecht |
| Yokohama FMarinos - Dinamo | Vélez Sársfield - Leicester City |
|
| Round 15 (36) | Round 16 (37) |
| Anderlecht - Bastia | Bastia - Belenenses |
| Belenenses - Dinamo | Besiktas - Fiorentina |
| Cagliari - Vélez Sársfield | Club Brugge - Yokohama FMarinos |
| FC Utrecht - Shakhtar | Dinamo - FC Utrecht |
| Fiorentina - Olympiakos | Everton - Anderlecht |
| Leicester City - Club Brugge | Hajduk Split - Cagliari |
| Lens - Mallorca | Mallorca - River Plate |
| River Plate - Torino | Olympiakos - Lens |
| Sassuolo - Hajduk Split | Shakhtar - Leicester City |
| Udinese - Besiktas | Torino - Sassuolo |
| Yokohama FMarinos - Everton | Vélez Sársfield - Udinese |
|
| Round 17 (38) | Round 18 (39) |
| Cagliari - Leicester City | Anderlecht - Belenenses |
| Everton - Bastia | Cagliari - Olympiakos |
| FC Utrecht - Anderlecht | FC Utrecht - Everton |
| Fiorentina - Udinese | Fiorentina - River Plate |
| Hajduk Split - River Plate | Hajduk Split - Bastia |
| Mallorca - Belenenses | Lens - Club Brugge |
| Olympiakos - Besiktas | Mallorca - Leicester City |
| Sassuolo - Lens | Sassuolo - Dinamo |
| Shakhtar - Yokohama FMarinos | Shakhtar - Besiktas |
| Torino - Dinamo | Udinese - Yokohama FMarinos |
| Vélez Sársfield - Club Brugge | Vélez Sársfield - Torino |
|
| Round 19 (40) | Round 20 (41) |
| Bastia - FC Utrecht | Anderlecht - River Plate |
| Belenenses - Udinese | Cagliari - Bastia |
| Besiktas - Lens | FC Utrecht - Besiktas |
| Club Brugge - Sassuolo | Fiorentina - Dinamo |
| Dinamo - Hajduk Split | Hajduk Split - Olympiakos |
| Everton - Fiorentina | Lens - Yokohama FMarinos |
| Leicester City - Anderlecht | Mallorca - Torino |
| Olympiakos - Mallorca | Sassuolo - Belenenses |
| River Plate - Cagliari | Shakhtar - Club Brugge |
| Torino - Shakhtar | Udinese - Leicester City |
| Yokohama FMarinos - Vélez Sársfield | Vélez Sársfield - Everton |
|
| Round 21 (42) |
| Bastia - Vélez Sársfield |
| Belenenses - FC Utrecht |
| Besiktas - Sassuolo |
| Club Brugge - Fiorentina |
| Dinamo - Cagliari |
| Everton - Mallorca |
| Leicester City - Lens |
| Olympiakos - Shakhtar |
| River Plate - Udinese |
| Torino - Hajduk Split |
| Yokohama FMarinos - Anderlecht |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Anderlecht - Yokohama FMarinos, Cagliari - Dinamo etc. |