| Round 5 | | Cagliari | 4 | 6 Romagna, 18 Farias, 22 João Pedro, 52 João Pedro | | Half-time: | 3-0 | | Referee: | Faktor 8 | | Attendance: | 23,304 | | Possession: | 45%-55% | | Total shots: | 12-11 | | MoM: | Gourna-Douath |
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| | (4-3-3): Cragno 7, Zappa 7, Lykogiannis 7, Cigarini 8, Romagna 6½, Ceppitelli 6½, Ionita 7, Sau 5 (70 Piccini 6), João Pedro 7½, Cutrone 6, Farias 7½ | | Belenenses | 0 |
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| | (4-3-3): Hansen 7, Cannon 6, Matheus Reis 6½, Gourna-Douath 8, Zanka 7½, Necip 7 (60 Hovland 6), Bakayoko 8, Yttergård Jenssen 6, Banza 7½, Pérez 7 (67 Meling 6), Peñaranda 6½ | | Everton | 2 | 69 Cenk, 78 André Gomes | | Half-time: | 0-0 | | Referee: | Khussainov 5½ | | Attendance: | 40,389 | | Possession: | 55%-45% | | Total shots: | 21-11 | | MoM: | Hartman |
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| | (4-3-3): Vicario 7, Godfrey 8, Hartman 8½, André Gomes 7, Bartra 7½, Mina 6½, Traoré 7, Rodríguez 7, Cenk 6½, Gbamin 6½, Vázquez 6 | | Lens | 1 | 67 Ikoné |
| | (4-3-3): Léo 6½, Cash 7, Lima 7, Lemina 7½, Gradit 6½ (68 Le Cardinal 6½), Jullien 5½, Fortés 7, Ikoné 6½, Omrani 7, Nkoudou 5½, Touzghar 6 | | FC Utrecht | 1 | 25 Toornstra | | Half-time: | 1-0 | | Referee: | Díaz Vega 6½ | | Attendance: | 23,612 | | Possession: | 44%-56% | | Total shots: | 12-14 | | MoM: | Kraft | | TV: | highlights |
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| | (4-3-3): Paes 7½, Klaiber 6½, Smal 7, Warmerdam 7½, Martins-Indi 6, Ter Avest 6½, Toornstra 7, Boussaid 6½ (65 Van Der Maarel 7), Kramer 6½, Gustafsson 7, Bahebeck 5½ | | River Plate | 0 |
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| | (4-3-3): Kraft 7½, Molina 7½, Funes Mori 7½, Allan 6½ (82 Martínez 6), Díaz 7, Mammana 7, De La Vega 7, Fernández 7, Solari 7, Pérez 6½, Beltrán 6 | | Fiorentina | 1 | 10 Nzola | | Half-time: | 1-0 | | Referee: | Ziober 7 | | Attendance: | 35,010 | | Possession: | 52%-48% | | Total shots: | 21-12 | | MoM: | Parisi |
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| | (4-3-3): Terracciano 7½, Pierozzi 7½, Hickey 7, Barák 7, Dalle Mura 7, Parisi 7½, Castrovilli 7, Bonaventura 6½, Nzola 7, Soriano 6½, Infantino 6 | | Yokohama FMarinos | 1 | 50 Ljajic |
| | (4-3-3): Sirigu 6½, Isla 7, Sakho 7, Iwata 7, Radu 6, Yoshida 6½, Kuba 6, Ljajic 7, Gameiro 6, Nakamura 5½, Ueda 6 | | Hajduk Split | 2 | 54 Sulejmani, 77p Joselu | | Half-time: | 0-0 | | Referee: | Hauge 7½ | | Attendance: | 41,518 | | Possession: | 54%-46% | | Total shots: | 16-12 | | MoM: | Besirevic |
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| | (4-3-3): Shunin 7, Juranovic 7, Barisic 7½, Besirevic 8, Jedvaj 7½, Mikulic 6½, Sehic 6½, Sulejmani 7, Joselu 7, Kalinic 6, Ivanovski 7 | | Besiktas | 0 |
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| | (4-3-3): Mert 7½, Vida 8, Caner 7, Elneny 6, Welinton 7, Roco 6, Douglas 7½, Perotti 6, Destro 6½, Aboubakar 6, Valencia 5½ | | Mallorca | 2 | 15 Budimir, 18 Abel Ruiz | | Half-time: | 2-1 | | Referee: | Cesari 7 | | Attendance: | 23,050 | | Possession: | 44%-56% | | Total shots: | 11-8 | | MoM: | Abel Ruiz |
| | 55 Lago Junior | | (4-3-3): Rajkovic 7, Sastre 7, Diego Rico 8, Baba 6 (54 Álex 7½), Valjent 6½, Raillo 6½, Pina 5½, Abel Ruiz 8, Budimir 7½, Cucho 6, Lago Junior 5½ | | Club Brugge | 1 | 2 Nusa | | 35 Vanaken, 76 Clinton | | (4-3-3): Mignolet 7½, Clinton 7½, Buchanan 7, Vanaken 7, Mechele 7½, Hendry 6½, Rits 7, Nusa 7½, Larin 6½, Nielsen 7½, Pérez 6 | | Olympiakos | 1 | 70 Camara | | Half-time: | 0-0 | | Referee: | Rudy 6½ | | Attendance: | 32,915 | | Possession: | 51%-49% | | Total shots: | 14-12 | | MoM: | Williams |
| | 6 Tiago Silva, 37 Semedo | | (4-3-3): José Sá 7, Cissé 7, Holebas 7, Tiago Silva 6½, Semedo 6½, Ba 6½, Vrousai 5½, Bruma 7, Bakambu 6, Camara 7, Soudani 6 | | Leicester City | 1 | 64 Lang | | 56 Oxlade-Chamberlain, 84 Jensen, 90 Ekitiké | | (4-3-3): Dúbravka 7½, Williams 8, Thomas 6, Oxlade-Chamberlain 7, Sánchez 7½, Amartey 6, Gray 8, Lang 7½, Hirst 6, Jensen 6, Ekitiké 6½ | | Sassuolo | 2 | 28 Raspadori, 57og Núñez | | Half-time: | 1-1 | | Referee: | Ancion 7 | | Attendance: | 20,444 | | Possession: | 39%-61% | | Total shots: | 10-15 | | MoM: | Bustos |
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| | (4-3-3): Consigli 6½, Pedersen 6 (71 Lipani 6½), Rogério 6, Bajrami 7, Erlic 6½, Viti 7, Boloca 7 (73 Mulattieri 6½), Samu Castillejo 7, Raspadori 6½, Ceide 6, Laurienté 5½ | | Bastia | 2 | 20 Carrillo, 90 Dirar | | 21 Bakayoko, 90+2 Núñez | | (4-3-3): Álvarez 7, Gajic 7, Ballo-Toure 7, Capoue 6 (90+1 Storm 6), Konaté 7 (90+1 Aranda 6), Núñez 6½, Bustos 7½, Dirar 6½, Carrillo 6½, Bakayoko 7, Keane 7 | | Shakhtar | 1 | 58 Solomon | | Half-time: | 0-1 | | Referee: | Detruche 7½ | | Attendance: | 40,349 | | Possession: | 48%-52% | | Total shots: | 12-11 | | MoM: | João Mário |
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| | (4-3-3): Lastuvka 6, João Mário 8, Ismaily 7½, Florentino Luís 7½, Zabarnyi 6½, Tarkowski 6, Tetê 6½, Solomon 8, Traoré 6½, Stepanenko 6½, Colley 6½ (73 Ordets 5½) | | Udinese | 2 | 45+3 Gerard, 59 Walace | | 1 Success, 41 Ebosele | | (4-3-3): Silvestri 6½, Ehizibue 7½, Zemura 7½, Lovric 7½, Bijol 7, Kabasele 6½, Ebosele 6½, Gerard 7½, Davis 6½, Walace 5½, Success 5½ | | Torino | 0 |
| | Half-time: | 0-0 | | Referee: | Onufer 6 | | Attendance: | 27,925 | | Possession: | 51%-49% | | Total shots: | 12-8 | | MoM: | Petagna | | TV: | live |
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| | (4-3-3): Milinkovic-Savic 6½, Djidji 7, Vojvoda 6½, Linetty 7½, Buongiorno 6½, Schuurs 6½, Cherki 7, Vlasic 7, Petagna 8, Tameze 6½, Gineitis 5½ | | Anderlecht | 1 | 50 Ingvartsen |
| | (4-3-3): Verbruggen 6½, Delcroix 6, Targett 7, Malinovskyi 7 (80 Refaelov 6), Debast 7½, Ashimeru 6, Lukebakio 7½, Pedro Gonçalves 6½, Ingvartsen 7, Diawara 6½, Raman 6½ | | Vélez Sársfield | 1 | 77 Janson | | Half-time: | 0-0 | | Referee: | Sarvan 7 | | Attendance: | 33,688 | | Possession: | 51%-49% | | Total shots: | 14-16 | | MoM: | Babic |
| | 17 Ortega, 23 Barco | | (4-3-3): Hoyos 6, Advíncula 7, Fabra 7½, Barco 6, De Los Santos 6½, Giannetti 7, Orellano 7, Colidio 7, Pratto 7½, Ortega 6, Janson 6½ | | Dinamo | 2 | 46 Grulev, 57 Chalov | | 76 Grulev | | (4-3-3): Akinfeev 7, Parshivlyuk 7½, Skopintsev 7, Zakharyan 7½, Babic 8, Balbuena 6, Fomin 7, Mostovoy 7½, Grulev 6, Okay 5½, Chalov 6 | | Round 4 | | Dinamo | 0 |
| | Half-time: | 0-0 | | Referee: | Michel 7 | | Attendance: | 35,209 | | Possession: | 51%-49% | | Total shots: | 15-14 | | MoM: | Akinfeev |
| | 26 Fomin | | (4-3-3): Akinfeev 7½, Parshivlyuk 7, Skopintsev 6½, Zakharyan 7½, Babic 7½, Balbuena 6, Fomin 7, Mostovoy 7, Grulev 6, Bakaev 6, Chalov 7 | | Shakhtar | 0 |
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| | (4-3-3): Lastuvka 7½, João Mário 6½, Ismaily 7, Florentino Luís 7½, Zabarnyi 7½, Tarkowski 6½, Tetê 7½, Solomon 7, Traoré 6, Kovalenko 6, Colley 6 |
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