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| Round 1 (22) 1.FC Köln - Lazio Anderlecht - Racing Club Catania - Feyenoord Corinthians - Chelsea Eintr. Frankfurt - Real Madrid Espanyol - Melbourne Victory FC Basel - Dnipro Fluminense - Genoa Internacional - Elche Leicester City - Sassuolo Sunderland - Estudiantes (LP) | Round 2 (23) Chelsea - Espanyol Dnipro - Fluminense Elche - Anderlecht Estudiantes (LP) - Corinthians Feyenoord - FC Basel Genoa - Catania Lazio - Internacional Melbourne Victory - 1.FC Köln Racing Club - Sunderland Real Madrid - Leicester City Sassuolo - Eintr. Frankfurt |
| Round 3 (24) 1.FC Köln - Chelsea Anderlecht - Lazio Catania - Elche Corinthians - Feyenoord Eintr. Frankfurt - Genoa Espanyol - Real Madrid FC Basel - Sassuolo Fluminense - Estudiantes (LP) Internacional - Melbourne Victory Leicester City - Racing Club Sunderland - Dnipro | Round 4 (25) Chelsea - Anderlecht Dnipro - Leicester City Elche - Espanyol Estudiantes (LP) - Catania Feyenoord - Internacional Genoa - FC Basel Lazio - Corinthians Melbourne Victory - Sunderland Racing Club - Eintr. Frankfurt Real Madrid - Fluminense Sassuolo - 1.FC Köln |
| Round 5 (26) 1.FC Köln - Dnipro Anderlecht - Melbourne Victory Catania - Lazio Corinthians - Sassuolo Eintr. Frankfurt - Estudiantes (LP) Espanyol - Genoa FC Basel - Chelsea Fluminense - Racing Club Internacional - Real Madrid Leicester City - Feyenoord Sunderland - Elche | Round 6 (27) Catania - Anderlecht Corinthians - Sunderland Espanyol - Sassuolo Estudiantes (LP) - Feyenoord FC Basel - Eintr. Frankfurt Genoa - Real Madrid Internacional - 1.FC Köln Lazio - Chelsea Leicester City - Fluminense Melbourne Victory - Elche Racing Club - Dnipro |
| Round 7 (28) 1.FC Köln - Catania Anderlecht - Corinthians Chelsea - Melbourne Victory Dnipro - Espanyol Eintr. Frankfurt - Leicester City Elche - Lazio Feyenoord - Racing Club Fluminense - FC Basel Real Madrid - Estudiantes (LP) Sassuolo - Genoa Sunderland - Internacional | Round 8 (29) Chelsea - Fluminense Corinthians - Internacional Dnipro - Feyenoord Eintr. Frankfurt - Anderlecht Espanyol - 1.FC Köln Genoa - Elche Leicester City - FC Basel Melbourne Victory - Lazio Racing Club - Estudiantes (LP) Real Madrid - Sassuolo Sunderland - Catania |
| Round 9 (30) 1.FC Köln - Leicester City Anderlecht - Sunderland Catania - Corinthians Elche - Chelsea Estudiantes (LP) - Dnipro FC Basel - Racing Club Feyenoord - Real Madrid Fluminense - Eintr. Frankfurt Internacional - Espanyol Lazio - Genoa Sassuolo - Melbourne Victory | Round 10 (31) Dnipro - Chelsea Eintr. Frankfurt - Internacional Estudiantes (LP) - 1.FC Köln FC Basel - Catania Feyenoord - Elche Fluminense - Corinthians Genoa - Melbourne Victory Leicester City - Sunderland Racing Club - Espanyol Real Madrid - Lazio Sassuolo - Anderlecht |
| Round 11 (32) 1.FC Köln - Racing Club Anderlecht - FC Basel Catania - Fluminense Chelsea - Real Madrid Corinthians - Genoa Elche - Estudiantes (LP) Espanyol - Eintr. Frankfurt Internacional - Dnipro Lazio - Feyenoord Melbourne Victory - Leicester City Sunderland - Sassuolo | Round 12 (33) 1.FC Köln - Genoa Anderlecht - Fluminense Catania - Leicester City Chelsea - Feyenoord Corinthians - FC Basel Elche - Racing Club Espanyol - Estudiantes (LP) Internacional - Sassuolo Lazio - Dnipro Melbourne Victory - Eintr. Frankfurt Sunderland - Real Madrid |
| Round 13 (34) Dnipro - Elche Eintr. Frankfurt - Corinthians Estudiantes (LP) - Melbourne Victory FC Basel - Internacional Feyenoord - 1.FC Köln Fluminense - Espanyol Genoa - Sunderland Leicester City - Anderlecht Racing Club - Lazio Real Madrid - Catania Sassuolo - Chelsea | Round 14 (35) 1.FC Köln - FC Basel Anderlecht - Genoa Catania - Dnipro Chelsea - Racing Club Corinthians - Real Madrid Elche - Eintr. Frankfurt Espanyol - Leicester City Internacional - Estudiantes (LP) Lazio - Sassuolo Melbourne Victory - Feyenoord Sunderland - Fluminense |
| Round 15 (36) Dnipro - Melbourne Victory Eintr. Frankfurt - Catania Estudiantes (LP) - Lazio FC Basel - Sunderland Feyenoord - Espanyol Fluminense - 1.FC Köln Genoa - Chelsea Leicester City - Corinthians Racing Club - Internacional Real Madrid - Anderlecht Sassuolo - Elche | Round 16 (37) 1.FC Köln - Real Madrid Anderlecht - Feyenoord Catania - Sassuolo Chelsea - Estudiantes (LP) Corinthians - Dnipro Elche - Fluminense Espanyol - FC Basel Internacional - Genoa Lazio - Leicester City Melbourne Victory - Racing Club Sunderland - Eintr. Frankfurt |
| Round 17 (38) 1.FC Köln - Elche Anderlecht - Estudiantes (LP) Catania - Melbourne Victory Corinthians - Racing Club Eintr. Frankfurt - Dnipro Espanyol - Lazio FC Basel - Real Madrid Fluminense - Sassuolo Internacional - Chelsea Leicester City - Genoa Sunderland - Feyenoord | Round 18 (39) Anderlecht - Dnipro Catania - Espanyol Corinthians - Elche Eintr. Frankfurt - 1.FC Köln FC Basel - Lazio Fluminense - Feyenoord Genoa - Estudiantes (LP) Leicester City - Internacional Real Madrid - Melbourne Victory Sassuolo - Racing Club Sunderland - Chelsea |
| Round 19 (40) 1.FC Köln - Anderlecht Chelsea - Leicester City Dnipro - Genoa Elche - Real Madrid Espanyol - Corinthians Estudiantes (LP) - Sassuolo Feyenoord - Eintr. Frankfurt Internacional - Fluminense Lazio - Sunderland Melbourne Victory - FC Basel Racing Club - Catania | Round 20 (41) Anderlecht - Espanyol Catania - Internacional Corinthians - Melbourne Victory Eintr. Frankfurt - Chelsea FC Basel - Estudiantes (LP) Fluminense - Lazio Genoa - Feyenoord Leicester City - Elche Real Madrid - Racing Club Sassuolo - Dnipro Sunderland - 1.FC Köln |
| Round 21 (42) 1.FC Köln - Corinthians Chelsea - Catania Dnipro - Real Madrid Elche - FC Basel Espanyol - Sunderland Estudiantes (LP) - Leicester City Feyenoord - Sassuolo Internacional - Anderlecht Lazio - Eintr. Frankfurt Melbourne Victory - Fluminense Racing Club - Genoa | |
| League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above, i.e. round 42 is Anderlecht - Internacional, Catania - Chelsea etc. | |