| Round 12 | | Aston Villa | 0 |
| | Half-time: | 0-1 | | Referee: | Bates 6 | | Attendance: | 41,257 | | Possession: | 41%-59% | | Total shots: | 7-24 | | MoM: | Edmílson |
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| | (4-4-2): Fábio Costa 6½, Neill 7, Heinze 7, Laursen 7, Hofland 7, Landzaat 7, Schneider 7, N'Zogbia 7½, Defoe 7, Dessena 7 (76 Palacios 6), José Mari 6½ (82 Riki 6) | | Leicester City | 2 | 45 Marcelinho, 78 Marcelinho |
| | (4-4-2): Abbondanzieri 7½, Ljungberg 7½, Edman 7½, Mintál 6½, Edmílson 7½, Stankovic 7, Ujfalusi 6½, Nélson 7, Lucarelli 6½, Marcelinho 6½, Etxeberria 6½ | | Brighton & HA | 1 | 41 Kanouté | | Half-time: | 1-2 | | Referee: | Cable 6½ | | Attendance: | 17,541 | | Possession: | 40%-60% | | Total shots: | 6-13 | | MoM: | Juan | | TV: | highlights |
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| | (4-3-3): Saja 6½, Wolf 6½ (71 Diego Tristán 6½), Huddlestone 5½, Ooijer 6½, Melchiot 6, Banega 7 (81 Cannavaro 6), Baraja 6, Bresciano 6½, Liberopoulos 7, Kanouté 6½, Micoud 6½ | | Barnsley | 2 | 17 Jankulovski, 26 Del Piero |
| | (4-4-2): James 6½, Jankulovski 7½, Carragher 8, Terry 7½, Juan 8½, Cole 6½, Seedorf 7, Quaresma 8, Luís Fabiano 8, Giggs 8, Del Piero 7 | | Burnley | 0 |
| | Half-time: | 0-1 | | Referee: | Danson 7 | | Attendance: | 48,417 | | Possession: | 35%-65% | | Total shots: | 9-17 | | MoM: | Sagnol |
| | 78 Jagielka | | (4-3-3): Gordon 6, Young 6½, Neville 6, Noble 6½, Jagielka 6½, Ridgewell 6½, Fletcher 5½, Barton 6, Cole 7 (66 Fletcher 6½), Ireland 6½, Moore 5½ | | Arsenal | 2 | 38 Sagnol, 90+1 Keane | | 15 Keane, 20 Messi | | (4-3-3): Buffon 6½, Sagnol 8½, Maldini 7½, Diarra 7, Cannavaro 7½, Lúcio 6, Kaká 7, Xabi Alonso 6½, Keane 7½, Van Nistelrooy 7, Messi 7 | | Gillingham | 1 | 33 Toni | | Half-time: | 1-0 | | Referee: | Dowd 6½ | | Attendance: | 46,878 | | Possession: | 46%-54% | | Total shots: | 15-13 | | MoM: | Solari | | TV: | highlights |
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| | (4-4-2): Amelia 7½, Cicinho 6½, Moretti 7, Van Buyten 7, Mertesacker 6, Pedretti 6½, Mancini 6½, Adriano 7, Toni 7½, Hleb 7½, Eto'o 6 | | Birmingham City | 0 |
| | 73 Touré | | (4-4-2): Green 7½, Gurenko 7, De Cler 7, Giuly 6½, Cuéllar 6, Touré 6, Ferguson 7, Solari 7½, Inzaghi 6½ (66 Boyd 7), Van Bommel 7, Dindane 6 | | Manchester United | 0 |
| | Half-time: | 0-1 | | Referee: | Foy 5½ | | Attendance: | 58,036 | | Possession: | 41%-59% | | Total shots: | 9-12 | | MoM: | Lescott |
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| | (4-4-2): Víctor Valdés 6, Zambrotta 7, Evrà 7, Chivu 7½, Albiol 7, Carrick 7, Nani 7, Kanyuka 6, Reyes 6, Rooney 6½, Vicente 7 | | Nottingham Forest | 2 | 21 Di Michele, 72 McCarthy |
| | (4-2-4): Kirkland 6½, Hutton 7½, Lescott 8, Samba 8, Dunne 6½, Hunt 7½, Sidwell 7, Di Michele 6½, Bojinov 6, McCarthy 6½, Davies 6½ | | Port Vale | 1 | 67 Rosenberg | | Half-time: | 0-1 | | Referee: | Hill 6½ | | Attendance: | 34,199 | | Possession: | 42%-58% | | Total shots: | 10-11 | | MoM: | Cocu |
| | 78 Rosenberg | | (4-4-2): Wiese 6½, Lell 6½, Nesmachnyi 6, Perrotta 7½, Zaccardo 6½, Lugano 7, Källström 6½, Essien 7½, Crespo 7, Hitzlsperger 6½, Rosenberg 6½ | | Newcastle United | 1 | 22 Healy |
| | (4-4-2): Dida 7, Diana 8, Dedé 8, Wörns 7, Vermant 7½, Córdoba 7, Cocu 8, Javi Martínez 7, Cruz 7½, Davis 8, Healy 6 | | Reading | 1 | 67 Júlio Baptista | | Half-time: | 0-2 | | Referee: | Jones 6½ | | Attendance: | 24,975 | | Possession: | 46%-54% | | Total shots: | 12-13 | | MoM: | Richardson |
| | 40 Ibrahimovic | | (4-4-2): Stekelenburg 6, Maicon 6, Grosso 6½ (76 Richardson 8), Vieira 6½ (46 Rafael 7), Sagna 6, Barry 7, Camoranesi 7, Ernst 6½, Júlio Baptista 7, Ibrahimovic 7, Riera 7 | | Leeds United | 3 | 10 Di Natale, 13 Di Natale, 74 Di Natale |
| | (4-4-2): Frey 6½, Brown 7½, Bridge 7, Marchena 7½, Ricardo Carvalho 6½, Yobo 7, Hargreaves 7, Parker 7½, Yakubu 6, Di Natale 7 (81 Shevchenko 6), Arteta 7 | | Swansea City | 1 | 39 Montolivo | | Half-time: | 1-2 | | Referee: | Laws 8 | | Attendance: | 41,316 | | Possession: | 46%-54% | | Total shots: | 17-11 | | MoM: | Clichy |
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| | (4-4-2): Gomes 6, Osorio 7, Clichy 8½, Ignashevich 7½, Pepe 8, Escudé 6, Hamit 6½, Montolivo 6½, Milito 6, Jankovic 6½, Amauri 6 | | Chelsea | 2 | 23 Gallas, 34 Klose |
| | (4-4-2): Hélton 7, Kaladze 8, Melli 7, Pablo 7, Gallas 7½, Albelda 7, Riise 7½, Elano 7½, Cavenaghi 6½, Klose 6½, Schweinsteiger 6½ | | Tottenham Hotspur | 3 | 8 Ronaldinho, 12 Ronaldinho, 35 Ronaldinho | | Half-time: | 3-1 | | Referee: | Styles 6 | | Attendance: | 84,572 | | Possession: | 60%-40% | | Total shots: | 22-6 | | MoM: | Ribéry | | TV: | highlights |
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| | (3-1-3-3): Casillas 7, Miguel 7½, Abidal 7½, Mascherano 7, Puyol 8, Ribéry 8, Ronaldinho 7, Iniesta 6½, Vílla 7½, Simão 7½, Tévez 7½ | | Watford | 1 | 4 Zurawski | | 34 Beasley, 84 Finnan | | (4-3-3): Van Der Sar 6, Finnan 6½, Arruabarrena 7, Distin 7½, Bordon 6, Aufhauser 6½, Brighi 7, Beasley 5½, Zurawski 7½, Slory 5½, Frau 7 | | Wrexham | 0 |
| | Half-time: | 0-0 | | Referee: | Crick 7 | | Attendance: | 53,093 | | Possession: | 42%-58% | | Total shots: | 3-13 | | MoM: | Ferdinand | | TV: | live |
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| | (4-3-3): Cech 6½, Friedrich 7½, Lahm 7, Demichelis 7½, Metzelder 7 (66 Cardozo 6½), Sneijder 7½, Joaquín 7, Poulsen 6½, Gomez 7 (66 Govou 6½), Rakitic 6½, Downing 5½ | | Liverpool | 1 | 58 Henry |
| | (3-5-2): Reina 7, Fabregas 8, Nasri 6 (76 Robben 6), Sergio Ramos 7, Ferdinand 8, Nesta 7½, Lampard 8, Gerrard 7, Fernando Torres 7½, Pirlo 7, Henry 7 |
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