| Round 21 | | Arsenal | 1 | 26 Neville | | Half-time: | 1-1 | | Referee: | Rennie 6½ | | Attendance: | 88,800 | | Possession: | 51%-49% | | Total shots: | 11-14 | | MoM: | Neville | | TV: | live |
| | 78 Messi | | (4-3-3): Buffon 7, Neville 8, Maldini 6½, Diarra 6½, Cannavaro 7½, Lúcio 6½, Kaká 7, Xabi Alonso 6½, Messi 7½, Van Nistelrooy 6½, Van Persie 6 | | Gillingham | 2 | 38 Rodríguez, 47 Eto'o | | 35 Eto'o | | (4-4-2): Amelia 6, Diarra 7, Cole 7, Van Buyten 7½, Mertesacker 6½, Ernst 6, Rodríguez 7, Adriano 6½, Toni 7, Arshavin 7½, Eto'o 7 | | Aston Villa | 3 | 13 Krzynowek, 56 Krzynowek, 70 Bouma | | Half-time: | 1-0 | | Referee: | Knight 7 | | Attendance: | 41,347 | | Possession: | 42%-58% | | Total shots: | 10-10 | | MoM: | Scholes |
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| | (4-3-3): Volkan 7½, Johnson 6½, Bouma 7, Deco 6½, Gavrancic 6, Neill 6, Faubert 6, Krzynowek 7, Riki 6½, O'Shea 7, José Mari 5½ | | Manchester United | 0 |
| | 89 Nani | | (4-3-3): Víctor Valdés 7½, Zambrotta 8, Evrà 8, Chivu 7, Albiol 7, Carrick 8, Scholes 8½, Vidal 7½, Cristiano Ronaldo 8½, Cruz 6, Nani 7 | | Barnsley | 3 | 12 Raúl, 45 Raúl, 61 Del Piero | | Half-time: | 2-0 | | Referee: | Penicka 6½ | | Attendance: | 69,888 | | Possession: | 58%-42% | | Total shots: | 14-4 | | MoM: | Giggs |
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| | (4-4-2): James 8, Juan 8, Carragher 7½, Terry 8, King 7, Quaresma 8, Kranjcar 7, Giggs 8, Del Piero 8, Raúl 7, Seedorf 6½ | | QPR | 0 |
| | 14 Torrado, 75 Gabi, 78 Koevermans, 80 Valdez, 86 Lewandowski | | (4-4-2): Shovkovskyi 7, Haggui 7, Lewandowski 7, Mehmet 7 (61 Koevermans 6½), Grygera 7, Caneira 7 (66 Valdez 6½), Renato 6, Petrov 6½, Anelka 7, Torrado 6, Gabi 6 | | Birmingham City | 2 | 45+1 Dindane, 55 Dindane | | Half-time: | 1-0 | | Referee: | Wiley 7 | | Attendance: | 40,731 | | Possession: | 51%-49% | | Total shots: | 15-12 | | MoM: | Giuly |
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| | (4-4-2): Boruc 7½, Gurenko 7½, De Cler 7½, Giuly 8, Touré 7½, Kovac 7, Van Bommel 7½, Adam 6½, Crespo 7½, Émerson 7, Dindane 7 | | Burnley | 0 |
| | 8 Jagielka, 23 Davis | | (4-3-3): Gordon 7½, Taylor 7 (66 Barton 7), Neville 7, Fletcher 7½, Dawson 7, Jagielka 6½, Bentley 7, O'Neil 6, Cole 8, Davis 7, Fletcher 6 | | Derby County | 2 | 4 Vieira, 69 Nedved | | Half-time: | 1-0 | | Referee: | Webb 7 | | Attendance: | 41,744 | | Possession: | 51%-49% | | Total shots: | 9-7 | | MoM: | Yobo |
| | 30 Suazo, 35 Frings, 83 Mikel | | (4-4-2): Ricardo 6½ (81 Pouplin 6), Berezutsky 7, Reveillère 6½, Antonio López 6½, Gattuso 6 (76 Mikel 6), Samuel 6½, Ricardo Oliveira 6, Nedved 7½, Suazo 6, Vieira 6½, Frings 7 | | Leeds United | 1 | 48 Hargreaves |
| | (4-1-3-2): Rui Patrício 6½, Ricardo Carvalho 7, Marchena 6½, Yobo 7½, Heinze 7½, Hargreaves 7, Cahill 6½ (70 Kahlenberg 6), Parker 6½, Yakubu 5½, Di Natale 7 (70 Robinson 6), Arteta 7½ | | Liverpool | 4 | 7 Fernando Torres, 23 Fernando Torres, 84og Ignashevich, 86 Fernando Torres | | Half-time: | 2-1 | | Referee: | Walton 7½ | | Attendance: | 72,752 | | Possession: | 50%-50% | | Total shots: | 16-10 | | MoM: | Fernando Torres | | TV: | highlights |
| | 25 Fabregas | | (3-4-3): Hart 6, Daniel 7, Sneijder 5 (72 Alexandre Pato 6), Mexès 7, Ferdinand 7½, Chiellini 6, Lampard 6½ (73 Milner 6), Fabregas 6, Fernando Torres 8, Ronaldinho 6½, Henry 7 | | Swansea City | 2 | 30 Benzema, 72 Totti | | 22 Escudé | | (4-4-2): Gomes 6½, Miguel 7, Clichy 7, Ignashevich 7½, Pepe 7, Escudé 7, Hamit 6½, Montolivo 6, Totti 7, Hleb 6, Benzema 5½ | | Nottingham Forest | 0 |
| | Half-time: | 0-0 | | Referee: | Beeby 6½ | | Attendance: | 53,628 | | Possession: | 51%-49% | | Total shots: | 10-12 | | MoM: | Davies | | TV: | highlights |
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| | (4-3-3): Kirkland 7, Ángel 7½, Shorey 7, Davies 7½, Dunne 7½, Rafael 7, Sidwell 7, De Guzman 7½, Davies 7, Marcelo Mattos 6½, Riera 6½ | | Leicester City | 0 |
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| | (4-4-2): Abbondanzieri 6½, Etxeberria 7, Ujfalusi 7, Stankovic 6½, Tamas 7, Mintál 6, Edmílson 6, Nélson 7, Pizarro 6, Ljungberg 7, López 7 | | Reading | 1 | 24 Ibrahimovic | | Half-time: | 1-2 | | Referee: | Dowd 6½ | | Attendance: | 24,882 | | Possession: | 44%-56% | | Total shots: | 13-19 | | MoM: | Abidal |
| | 54 Ibrahimovic | | (4-4-2): Robinson 6½, Rafinha 8, Grosso 7 (76 Torbinsky 6), Ambrosini 6½ (46 Berg 7), Sagna 7, Luizão 6½, Fábio Simplício 6½, Barry 6, Defoe 7½, Ibrahimovic 6½, Malouda 6½ | | Tottenham Hotspur | 2 | 8 Iniesta, 33 Puyol | | 13 Marquez, 29 Maicon, 90+3 Ribéry | | (3-1-4-2): Casillas 6½, Marquez 7, Abidal 8, Mascherano 6½, Puyol 6, Diego 7½, Vílla 6½, Iniesta 6, Berbatov 6½, Maicon 7, Ribéry 7 | | WBA | 1 | 87 Iaquinta | | Half-time: | 0-1 | | Referee: | D'Urso 6½ | | Attendance: | 25,049 | | Possession: | 38%-62% | | Total shots: | 3-20 | | MoM: | Zaccardo | | TV: | highlights |
| | 35 Landzaat | | (4-4-2): Doni 6, Lescott 6½, Jiránek 6½, Rozehnal 7, Molinaro 7½, Hamsyk 7, Young 7, Landzaat 6½, Iaquinta 6, Simons 6, Cassano 6½ | | Port Vale | 2 | 16 Källström, 87 Simão |
| | (4-4-2): Wiese 7, Zaccardo 8½, Nesmachnyi 7, Perrotta 8½, Fernando Meira 8, Lugano 7, Källström 7, Essien 6½, Jones 7, Kovac 7½, Simão 7 | | Wrexham | 1 | 62 Robben | | Half-time: | 0-0 | | Referee: | Clattenburg 5 | | Attendance: | 50,430 | | Possession: | 55%-45% | | Total shots: | 17-11 | | MoM: | Friedrich |
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| | (4-3-3): Cech 7½, Zabaleta 6½, Lahm 7½, Friedrich 8, Demichelis 7, Poulsen 7½, Joaquín 7½, Bodmer 6½, Gomez 6½ (76 Godín 6½), Nasri 7, Robben 6½ | | Chelsea | 0 |
| | 24 Cavenaghi, 32 Albelda, 78 Berezutsky | | (4-4-2): Stijnen 7, Kaladze 7, Gallas 7, Pablo 7, Berezutsky 7, Albelda 7, Schweinsteiger 7, Elano 7, Cavenaghi 6½, Menez 6½, Navas 6½ | | Round 22 | | Arsenal | 3 | 1 Messi, 49 Kaká, 79 Van Persie | | Half-time: | 1-0 | | Referee: | Hall 7½ | | Attendance: | 72,570 | | Possession: | 47%-53% | | Total shots: | 14-7 | | MoM: | Diarra |
| | 6 Diarra, 38 Buffon, 45 Cannavaro | | (4-3-3): Buffon 7, Neville 7, Maldini 7, Diarra 7½, Cannavaro 7, Lúcio 6½, Kaká 7, Xabi Alonso 6½, Messi 7, Van Nistelrooy 7, Van Persie 6½ | | Burnley | 0 |
| | 21 O'Neil, 33 Davis | | (4-3-3): Gordon 7, Taylor 7 (66 Barton 7), Neville 6½, Fletcher 7, Dawson 7, Jagielka 6½, Bentley 6½, O'Neil 7 (66 Fletcher 6½), Cole 7½, Davis 6½, Vassell 6 | | Chelsea | 2 | 8 Pablo, 67 Klose | | Half-time: | 1-0 | | Referee: | Mason 7½ | | Attendance: | 50,723 | | Possession: | 55%-45% | | Total shots: | 21-7 | | MoM: | Stijnen |
| | 22 Elano | | (4-4-2): Stijnen 8, Kaladze 7½, Gallas 7½, Pablo 7, Berezutsky 6½, Albelda 7, Robinho 8, Elano 7, Cavenaghi 7, Klose 7, Schweinsteiger 7½ | | WBA | 0 |
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| | (4-4-2): Doni 7, Lescott 7½, Jiránek 6½, Rozehnal 6½, Molinaro 8, Hamsyk 6½, Young 6½, Landzaat 6½, Iaquinta 6½, Simons 6½, Cassano 5½ | | Gillingham | 2 | 65 Toni, 85 Eto'o | | Half-time: | 0-0 | | Referee: | Weilandt 6½ | | Attendance: | 61,518 | | Possession: | 48%-52% | | Total shots: | 16-11 | | MoM: | Diarra |
| | 22 Ernst | | (4-4-2): Amelia 7½, Diarra 8, Cole 7, Van Buyten 6½, Mertesacker 6½, Ernst 6½, Rodríguez 6½, Adriano 7, Toni 7½, Arshavin 6½, Eto'o 7½ | | Aston Villa | 1 | 72 Shevchenko |
| | (4-3-3): Volkan 7, Johnson 7½, Bouma 6½, Deco 6½, Gavrancic 7, Neill 6, Osman 7½, Krzynowek 6½, Riki 6½, O'Shea 6½ (68 Faubert 6½), Shevchenko 6½ | | Leeds United | 2 | 67 Cahill, 73 Di Natale | | Half-time: | 0-0 | | Referee: | Vurens 6 | | Attendance: | 49,055 | | Possession: | 48%-52% | | Total shots: | 14-14 | | MoM: | Demichelis |
| | 21 Zelaya, 39 Yobo, 74 Kahlenberg, 75 Zelaya, 82 Yobo | | (4-1-3-2): Frey 6½, Ricardo Carvalho 6½, Marchena 6½, Yobo 6½, Bridge 7, Hargreaves 7, Cahill 6 (68 Kahlenberg 7), Parker 6, Zelaya 6, Di Natale 7, Arteta 7 | | Wrexham | 1 | 88 Lahm |
| | (4-3-3): Cech 7, Zabaleta 7 (68 Defour 7½), Lahm 7½, Friedrich 6½, Demichelis 7½, Poulsen 6½, Joaquín 6½, Bodmer 7 (68 Downing 6), Gomez 7, Nasri 6½, Robben 7 | | Leicester City | 1 | 28og Mehmet | | Half-time: | 1-1 | | Referee: | Lerch 6½ | | Attendance: | 33,687 | | Possession: | 43%-57% | | Total shots: | 9-16 | | MoM: | Etxeberria |
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| | (4-4-2): Abbondanzieri 7, Etxeberria 7½, Ujfalusi 7, Stankovic 7, Tamas 7, Mintál 6½, Edmílson 6, Nélson 7, Pizarro 7, Ljungberg 7, López 6 | | QPR | 1 | 27 Petrov | | 32 Gabi | | (4-4-2): Shovkovskyi 7, Haggui 7, Lewandowski 6, Mehmet 6, Grygera 7½, Caneira 7, Renato 6, Petrov 7 (76 Koevermans 6), Anelka 6, Torrado 6½, Gabi 6½ (66 Grønkjær 6½) | | Swansea City | 3 | 38 Pepe, 45+1 Amauri, 62og Terry | | Half-time: | 2-0 | | Referee: | Novotný 7½ | | Attendance: | 41,379 | | Possession: | 48%-52% | | Total shots: | 14-11 | | MoM: | Hamit |
| | 13 Ignashevich, 35 Escudé | | (4-4-2): Gomes 7, Miguel 6½, Clichy 7, Ignashevich 7, Pepe 6½, Escudé 6½, Hamit 8, Montolivo 6, Totti 6, Hleb 6, Amauri 6½ | | Barnsley | 1 | 57 Raúl | | 60 King | | (4-4-2): James 7½, Juan 7 (76 Petit 6), Carragher 7½, Terry 7, King 7½, Quaresma 7½, Kranjcar 7 (81 Guðjohnsen 6), Giggs 7½, Del Piero 8, Raúl 6½, Seedorf 7 |
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