| Round 38 | | Cardiff City | 0 |
| | Half-time: | 0-0 | | Referee: | Wiley 6 | | Attendance: | 15,529 | | Possession: | 60%-40% | | Total shots: | 18-8 | | MoM: | Frings |
| | 60 Buonanotte | | (4-3-3): Ustari 7, Squillaci 7, Abidal 7½, Mascherano 7, Marquez 7 (85 Afellay 6), Vermaelen 7, Frings 8, Perrotta 7½, Crouch 7, Makélélé 7, Buonanotte 6½ | | West Ham United | 1 | 63 Corradi |
| | (4-3-3): Kirkland 6½, Emerton 6, Borrowdale 6, El Karkouri 7, Wörns 7 (65 Butcher 7), Gallardo 6½, Carsley 6½, Zé Roberto 6½, Corradi 6, Diego Tristán 5½, López 5½ | | Chelsea | 0 |
| | Half-time: | 0-2 | | Referee: | Beeby 6 | | Attendance: | 45,334 | | Possession: | 49%-51% | | Total shots: | 11-15 | | MoM: | Rodríguez |
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| | (4-3-3): Carrizo 6, Cicinho 7½, Grosso 7, Hargreaves 6½, Demichelis 6½, Huddlestone 6, Rodríguez 7½, Vicente 6½, Defoe 6, Yakubu 5½, Asulin 5½ | | Exeter City | 2 | 27 Cavenaghi, 40 Messi |
| | (4-3-3): Casillas 7, Heitinga 7, Cole 7, Tévez 7½, Sergio Ramos 7½, Ricardo Carvalho 7½, Messi 6½ (88 Barzagli 6), Iniesta 7, Cavenaghi 7 (90 Chiellini 6), Barry 6, Agbonlahor 6 | | Coventry City | 2 | 21 Adebayor, 71 Emanuelson | | Half-time: | 1-0 | | Referee: | Dowd 6½ | | Attendance: | 28,536 | | Possession: | 51%-49% | | Total shots: | 21-10 | | MoM: | Deco |
| | 29 Gomes | | (4-3-3): Gomes 6½, Bosingwa 7½, Emanuelson 7, Deco 7½, Marchena 7, Molinaro 7, De Jong 7½, Santi 6½, Adebayor 6½, Gago 6, Adu 6 | | Blackpool | 1 | 88 Maniche |
| | (4-3-3): Johnsen 6½, Anyukov 7, Van Bronckhorst 7, Pires 7½, Perrin 6, Pasquale 7 (63 Zábavník 6½), Maniche 7, Hitzlsperger 7, Gökhan 7, Bruggink 6½, Milito 6 | | Liverpool | 2 | 17 Berbatov, 60 Wright-Phillips | | Half-time: | 1-1 | | Referee: | Marriner 7 | | Attendance: | 49,321 | | Possession: | 50%-50% | | Total shots: | 16-7 | | MoM: | Simão |
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| | (4-3-3): Wiese 6½, Daniel 7½, Maxwell 6½, Cole 7, Chivu 7½, Naldo 6, Wright-Phillips 6½, Simão 8, Berbatov 7, Cassano 7, Keane 6½ | | Oxford United | 1 | 19 Cocu | | 84 Clement | | (4-3-3): Gordon 6½, Diogo 6, Taylor 7, Jones 6, Clement 6½, Hughes 7½, Govou 6½, Cocu 7, Mido 6½, Gosling 5½, Folan 6½ | | Luton Town | 0 |
| | Half-time: | 0-0 | | Referee: | Foy 6 | | Attendance: | 43,524 | | Possession: | 55%-45% | | Total shots: | 17-5 | | MoM: | Cristiano Ronaldo | | TV: | highlights |
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| | (4-3-3): Romero 7, Jorge Andrade 7 (75 Lennon 7), Givet 7½, Stankovic 7, Samuel 7½, Cahais 6½, Joaquín 7½, Cristiano Ronaldo 7½, Ashton 7½, Mancini 6, Raúl 6½ | | Hull City | 1 | 48 Di Canio |
| | (4-3-3): Jääskeläinen 6½, Davis 6, Sennikov 6½, Edmílson 7½, Mertesacker 7 (76 Valerón 6), Shackell 6, Rosales 6½, Eagles 6½, Beattie 6½, Di Canio 6½, Delgado 5½ | | Manchester United | 5 | 2 Essien, 5 Eto'o, 20 Vílla, 30 Vílla, 57 Essien | | Half-time: | 4-0 | | Referee: | Riley 6½ | | Attendance: | 85,968 | | Possession: | 52%-48% | | Total shots: | 22-14 | | MoM: | Xavi |
| | 42 Robben | | (4-1-3-2): Reina 7, Gallas 7, Milito 8, Essien 7½, Carragher 7, De Jong 6½, Robben 7, Xavi 8, Vílla 8, Eto'o 7, Ribéry 7 | | Millwall | 1 | 51 Silvestre | | 35 Simic | | (4-3-3): Butina 7, Simic 5½, Silvestre 7½, Lurling 6, Moore 6, Craddock 6½, Meghni 5½, Ben Saada 6, Forssell 6½, Kitson 6, Tuncay 5½ | | Newcastle United | 1 | 90 Gilberto Silva | | Half-time: | 0-1 | | Referee: | Bennett 7 | | Attendance: | 51,969 | | Possession: | 43%-57% | | Total shots: | 8-9 | | MoM: | Evrà | | TV: | live |
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| | (4-3-3): Given 7, Adriano 6, Pasqual 8, Lampard 7½, Lúcio 7½, Pirlo 6½, Scholes 6½, Downing 6½, Van Nistelrooy 7, Kuranyi 5½, Totti 6½ (64 Gilberto Silva 6½) | | Arsenal | 1 | 13 Kaká |
| | (4-4-2): Buffon 7 (76 Carson 6), Evrà 8½, Cannavaro 6, Diego 6½, Maicon 6½, Cambiasso 7 (56 Albiol 7), Kaká 7, Robinho 7½, Ujfalusi 7½, Quagliarella 7, Fabregas 6½ | | Plymouth Argyle | 1 | 7 Kewell | | Half-time: | 1-0 | | Referee: | Halsey 6 | | Attendance: | 27,567 | | Possession: | 48%-52% | | Total shots: | 6-15 | | MoM: | Stearman | | TV: | highlights |
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| | (4-3-3): Taylor 6½, Miguel 6½ (68 Stearman 8), Raúl Bravo 6½, Sergio 7, Dunne 7, Upson 6½, Barnetta 8, Kewell 7 (68 Wilhelmsson 7), Santa Cruz 6½, Cissé 6, Semak 6½ | | Bradford City | 2 | 67 Gattuso, 84 Rosický | | 55 Gattuso | | (4-4-2): Júlio César 6½, Puyol 7, Panucci 6, Gattuso 7½, Touré 8, Vidic 7, Rosický 7, Nani 6½, Marin 6½, Rosina 6½, Ronaldinho 6½ | | Southampton | 3 | 24 Henry, 37 Henry, 79 Henry | | Half-time: | 2-0 | | Referee: | Rennie 6 | | Attendance: | 32,517 | | Possession: | 55%-45% | | Total shots: | 21-6 | | MoM: | Zambrotta |
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| | (4-4-2): Cech 7½, Mexès 7½, Zambrotta 8, Van Persie 7½, Nesta 7, Juan 6½, Del Piero 8, Vieira 7, Toni 8, Xabi Alonso 6½, Henry 7 | | Swansea City | 1 | 67 Warnock |
| | (4-3-3): Stekelenburg 7, Paulo Ferreira 6½, Warnock 7½, Poulsen 7, Cris 7, Sissoko 5½, Pennant 7½, Richardson 7 (55 Metzelder 6½), Tomlin 5½, Dacourt 6, Vassell 6 | | Sunderland | 1 | 85 Ferguson | | Half-time: | 0-0 | | Referee: | Dean 5½ | | Attendance: | 42,401 | | Possession: | 42%-58% | | Total shots: | 11-11 | | MoM: | Reveillère | | TV: | highlights |
| | 4 Ferdinand, 12 Quaresma, 43 Greening, 50 Kerzhakov, 58 Hunt, 67 Pugh | | (4-3-3): Álvarez 7, Mellberg 6½, Del Horno 7½, Ferguson 8, Ferdinand 6½, Hunt 6, Greening 6½ (85 Richards 6), Quaresma 8, Kerzhakov 6½, Pugh 6, Moreira 7 | | Derby County | 0 |
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| | (4-3-3): Hildebrand 8, Reveillère 8, Heinze 7, Ballack 7½, Hübschman 7½, Taylor 7½, Taddei 7, Khokhlov 7½, Ricardo Oliveira 6½, Óscar 7, Etxeberria 6½ | | Round 25 | | Bradford City | 1 | 11 Puyol | | Half-time: | 1-1 | | Referee: | Drysdale 6½ | | Attendance: | 24,961 | | Possession: | 55%-45% | | Total shots: | 14-12 | | MoM: | Zambrotta |
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| | (4-4-2): Júlio César 7, Puyol 7, Panucci 8, Gattuso 7½, Touré 7½, Vidic 6, Rosický 6½, Nani 7, Marin 7, Rosina 7, Ronaldinho 6½ | | Southampton | 1 | 1 Toni |
| | (4-4-2): Cech 6½, Mexès 7, Zambrotta 8, Van Persie 7½, Nesta 6½, Juan 6½, Del Piero 7, Vieira 6½, Toni 7, Xabi Alonso 6½, Henry 6 | | Round 28 | | Newcastle United | 2 | 24 Van Nistelrooy, 37 Van Nistelrooy | | Half-time: | 2-2 | | Referee: | Whitestone 6 | | Attendance: | 51,981 | | Possession: | 46%-54% | | Total shots: | 9-12 | | MoM: | Lampard |
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| | (4-3-3): Given 7, Adriano 7, Pasqual 7, Lampard 8, Lúcio 7½, Pirlo 6, Camoranesi 7½, Downing 6½, Van Nistelrooy 7½, Anelka 6½, Totti 6 | | Cardiff City | 2 | 13 Frings, 19 Bodmer |
| | (4-3-3): Ustari 7½, Squillaci 6½, Abidal 6½, Mascherano 7½, Marquez 6½, Vermaelen 7, Frings 7, Perrotta 7, Crouch 7½, Bodmer 6, Buonanotte 6½ |
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