| Round 1 (22) | Round 2 (23) |
| Athletic Bilbao - Osasuna | Bayern München - Roma |
| Atlético-MG - Celta Vigo | Celta Vigo - Barcelona |
| Barcelona - Napoli | Fiorentina - Sampdoria |
| Manchester City - Torino | Independiente - Valencia |
| Milan - Real Madrid | Lille - TSG Hoffenheim |
| Roma - Fiorentina | Napoli - Manchester City |
| Sampdoria - Bayern München | Osasuna - West Ham United |
| Sassuolo - Lille | Palmeiras - Milan |
| TSG Hoffenheim - SC Heerenveen | Real Madrid - Sassuolo |
| Valencia - Palmeiras | SC Heerenveen - Athletic Bilbao |
| West Ham United - Independiente | Torino - Atlético-MG |
|
| Round 3 (24) | Round 4 (25) |
| Athletic Bilbao - Lille | Bayern München - Manchester City |
| Atlético-MG - Independiente | Celta Vigo - West Ham United |
| Barcelona - Fiorentina | Fiorentina - Athletic Bilbao |
| Manchester City - Real Madrid | Independiente - TSG Hoffenheim |
| Milan - Napoli | Lille - Valencia |
| Roma - Palmeiras | Napoli - Roma |
| Sampdoria - Torino | Osasuna - Sassuolo |
| Sassuolo - Celta Vigo | Palmeiras - Sampdoria |
| TSG Hoffenheim - Bayern München | Real Madrid - Atlético-MG |
| Valencia - Osasuna | SC Heerenveen - Milan |
| West Ham United - SC Heerenveen | Torino - Barcelona |
|
| Round 5 (26) | Round 6 (27) |
| Athletic Bilbao - Napoli | Atlético-MG - Valencia |
| Atlético-MG - Osasuna | Barcelona - Sampdoria |
| Barcelona - Lille | Osasuna - Lille |
| Manchester City - Palmeiras | Palmeiras - Napoli |
| Milan - Independiente | Real Madrid - Celta Vigo |
| Roma - Celta Vigo | Roma - Manchester City |
| Sampdoria - Real Madrid | SC Heerenveen - Independiente |
| Sassuolo - Fiorentina | Sassuolo - Milan |
| TSG Hoffenheim - Torino | TSG Hoffenheim - Fiorentina |
| Valencia - SC Heerenveen | Torino - Bayern München |
| West Ham United - Bayern München | West Ham United - Athletic Bilbao |
|
| Round 7 (28) | Round 8 (29) |
| Athletic Bilbao - Atlético-MG | Bayern München - Fiorentina |
| Bayern München - Real Madrid | Lille - Manchester City |
| Celta Vigo - Palmeiras | Milan - Atlético-MG |
| Fiorentina - Torino | Napoli - Celta Vigo |
| Independiente - Osasuna | Palmeiras - Real Madrid |
| Lille - SC Heerenveen | Roma - Barcelona |
| Manchester City - Barcelona | SC Heerenveen - Osasuna |
| Milan - West Ham United | Sampdoria - Valencia |
| Napoli - TSG Hoffenheim | Sassuolo - West Ham United |
| Sampdoria - Roma | TSG Hoffenheim - Athletic Bilbao |
| Valencia - Sassuolo | Torino - Independiente |
|
| Round 9 (30) | Round 10 (31) |
| Athletic Bilbao - Roma | Barcelona - Atlético-MG |
| Atlético-MG - Sassuolo | Bayern München - Osasuna |
| Barcelona - Palmeiras | Celta Vigo - Independiente |
| Celta Vigo - Bayern München | Fiorentina - Valencia |
| Fiorentina - SC Heerenveen | Manchester City - Sassuolo |
| Independiente - Lille | Napoli - Lille |
| Manchester City - Sampdoria | Palmeiras - TSG Hoffenheim |
| Osasuna - Torino | Real Madrid - Athletic Bilbao |
| Real Madrid - Napoli | Roma - Milan |
| Valencia - Milan | Sampdoria - West Ham United |
| West Ham United - TSG Hoffenheim | Torino - SC Heerenveen |
|
| Round 11 (32) | Round 12 (33) |
| Athletic Bilbao - Palmeiras | Athletic Bilbao - Torino |
| Atlético-MG - Manchester City | Atlético-MG - Roma |
| Independiente - Real Madrid | Independiente - Palmeiras |
| Lille - Bayern München | Lille - Celta Vigo |
| Milan - Fiorentina | Milan - Bayern München |
| Osasuna - Celta Vigo | Osasuna - Napoli |
| SC Heerenveen - Roma | SC Heerenveen - Sampdoria |
| Sassuolo - Torino | Sassuolo - Barcelona |
| TSG Hoffenheim - Sampdoria | TSG Hoffenheim - Real Madrid |
| Valencia - Barcelona | Valencia - Manchester City |
| West Ham United - Napoli | West Ham United - Fiorentina |
|
| Round 13 (34) | Round 14 (35) |
| Barcelona - West Ham United | Athletic Bilbao - Barcelona |
| Bayern München - Atlético-MG | Atlético-MG - Napoli |
| Celta Vigo - Athletic Bilbao | Independiente - Sampdoria |
| Fiorentina - Lille | Lille - Palmeiras |
| Manchester City - TSG Hoffenheim | Milan - Manchester City |
| Napoli - Independiente | Osasuna - Fiorentina |
| Palmeiras - Osasuna | SC Heerenveen - Celta Vigo |
| Real Madrid - SC Heerenveen | Sassuolo - Bayern München |
| Roma - Valencia | TSG Hoffenheim - Roma |
| Sampdoria - Sassuolo | Valencia - Torino |
| Torino - Milan | West Ham United - Real Madrid |
|
| Round 15 (36) | Round 16 (37) |
| Barcelona - Milan | Athletic Bilbao - Bayern München |
| Bayern München - Valencia | Atlético-MG - Fiorentina |
| Celta Vigo - TSG Hoffenheim | Independiente - Manchester City |
| Fiorentina - Independiente | Lille - Real Madrid |
| Manchester City - Athletic Bilbao | Milan - Sampdoria |
| Napoli - SC Heerenveen | Osasuna - Roma |
| Palmeiras - West Ham United | SC Heerenveen - Palmeiras |
| Real Madrid - Osasuna | Sassuolo - Napoli |
| Roma - Sassuolo | TSG Hoffenheim - Barcelona |
| Sampdoria - Atlético-MG | Valencia - Celta Vigo |
| Torino - Lille | West Ham United - Torino |
|
| Round 17 (38) | Round 18 (39) |
| Athletic Bilbao - Independiente | Atlético-MG - TSG Hoffenheim |
| Atlético-MG - SC Heerenveen | Barcelona - Osasuna |
| Barcelona - Bayern München | Bayern München - SC Heerenveen |
| Manchester City - Fiorentina | Fiorentina - Palmeiras |
| Milan - Celta Vigo | Manchester City - Celta Vigo |
| Roma - Torino | Milan - Lille |
| Sampdoria - Napoli | Roma - West Ham United |
| Sassuolo - Palmeiras | Sampdoria - Athletic Bilbao |
| TSG Hoffenheim - Osasuna | Sassuolo - Independiente |
| Valencia - Real Madrid | Torino - Real Madrid |
| West Ham United - Lille | Valencia - Napoli |
|
| Round 19 (40) | Round 20 (41) |
| Athletic Bilbao - Valencia | Atlético-MG - West Ham United |
| Celta Vigo - Sampdoria | Barcelona - Real Madrid |
| Independiente - Bayern München | Bayern München - Palmeiras |
| Lille - Roma | Fiorentina - Napoli |
| Napoli - Torino | Manchester City - Osasuna |
| Osasuna - Milan | Milan - Athletic Bilbao |
| Palmeiras - Atlético-MG | Roma - Independiente |
| Real Madrid - Fiorentina | Sampdoria - Lille |
| SC Heerenveen - Barcelona | Sassuolo - SC Heerenveen |
| TSG Hoffenheim - Sassuolo | Torino - Celta Vigo |
| West Ham United - Manchester City | Valencia - TSG Hoffenheim |
|
| Round 21 (42) |
| Athletic Bilbao - Sassuolo |
| Celta Vigo - Fiorentina |
| Independiente - Barcelona |
| Lille - Atlético-MG |
| Napoli - Bayern München |
| Osasuna - Sampdoria |
| Palmeiras - Torino |
| Real Madrid - Roma |
| SC Heerenveen - Manchester City |
| TSG Hoffenheim - Milan |
| West Ham United - Valencia |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Atlético-MG - Lille, Barcelona - Independiente etc. |