| Round 1 (22) | Round 2 (23) |
| 1.FC Köln - Lazio | Chelsea - Espanyol |
| Anderlecht - Racing Club | Dnipro - Fluminense |
| Catania - Feyenoord | Elche - Anderlecht |
| Corinthians - Chelsea | Estudiantes (LP) - Corinthians |
| Eintr. Frankfurt - Real Madrid | Feyenoord - FC Basel |
| Espanyol - Melbourne Victory | Genoa - Catania |
| FC Basel - Dnipro | Lazio - Internacional |
| Fluminense - Genoa | Melbourne Victory - 1.FC Köln |
| Internacional - Elche | Racing Club - Sunderland |
| Leicester City - Sassuolo | Real Madrid - Leicester City |
| Sunderland - Estudiantes (LP) | Sassuolo - Eintr. Frankfurt |
|
| Round 3 (24) | Round 4 (25) |
| 1.FC Köln - Chelsea | Chelsea - Anderlecht |
| Anderlecht - Lazio | Dnipro - Leicester City |
| Catania - Elche | Elche - Espanyol |
| Corinthians - Feyenoord | Estudiantes (LP) - Catania |
| Eintr. Frankfurt - Genoa | Feyenoord - Internacional |
| Espanyol - Real Madrid | Genoa - FC Basel |
| FC Basel - Sassuolo | Lazio - Corinthians |
| Fluminense - Estudiantes (LP) | Melbourne Victory - Sunderland |
| Internacional - Melbourne Victory | Racing Club - Eintr. Frankfurt |
| Leicester City - Racing Club | Real Madrid - Fluminense |
| Sunderland - Dnipro | Sassuolo - 1.FC Köln |
|
| Round 5 (26) | Round 6 (27) |
| 1.FC Köln - Dnipro | Catania - Anderlecht |
| Anderlecht - Melbourne Victory | Corinthians - Sunderland |
| Catania - Lazio | Espanyol - Sassuolo |
| Corinthians - Sassuolo | Estudiantes (LP) - Feyenoord |
| Eintr. Frankfurt - Estudiantes (LP) | FC Basel - Eintr. Frankfurt |
| Espanyol - Genoa | Genoa - Real Madrid |
| FC Basel - Chelsea | Internacional - 1.FC Köln |
| Fluminense - Racing Club | Lazio - Chelsea |
| Internacional - Real Madrid | Leicester City - Fluminense |
| Leicester City - Feyenoord | Melbourne Victory - Elche |
| Sunderland - Elche | Racing Club - Dnipro |
|
| Round 7 (28) | Round 8 (29) |
| 1.FC Köln - Catania | Chelsea - Fluminense |
| Anderlecht - Corinthians | Corinthians - Internacional |
| Chelsea - Melbourne Victory | Dnipro - Feyenoord |
| Dnipro - Espanyol | Eintr. Frankfurt - Anderlecht |
| Eintr. Frankfurt - Leicester City | Espanyol - 1.FC Köln |
| Elche - Lazio | Genoa - Elche |
| Feyenoord - Racing Club | Leicester City - FC Basel |
| Fluminense - FC Basel | Melbourne Victory - Lazio |
| Real Madrid - Estudiantes (LP) | Racing Club - Estudiantes (LP) |
| Sassuolo - Genoa | Real Madrid - Sassuolo |
| Sunderland - Internacional | Sunderland - Catania |
|
| Round 9 (30) | Round 10 (31) |
| 1.FC Köln - Leicester City | Dnipro - Chelsea |
| Anderlecht - Sunderland | Eintr. Frankfurt - Internacional |
| Catania - Corinthians | Estudiantes (LP) - 1.FC Köln |
| Elche - Chelsea | FC Basel - Catania |
| Estudiantes (LP) - Dnipro | Feyenoord - Elche |
| FC Basel - Racing Club | Fluminense - Corinthians |
| Feyenoord - Real Madrid | Genoa - Melbourne Victory |
| Fluminense - Eintr. Frankfurt | Leicester City - Sunderland |
| Internacional - Espanyol | Racing Club - Espanyol |
| Lazio - Genoa | Real Madrid - Lazio |
| Sassuolo - Melbourne Victory | Sassuolo - Anderlecht |
|
| Round 11 (32) | Round 12 (33) |
| 1.FC Köln - Racing Club | 1.FC Köln - Genoa |
| Anderlecht - FC Basel | Anderlecht - Fluminense |
| Catania - Fluminense | Catania - Leicester City |
| Chelsea - Real Madrid | Chelsea - Feyenoord |
| Corinthians - Genoa | Corinthians - FC Basel |
| Elche - Estudiantes (LP) | Elche - Racing Club |
| Espanyol - Eintr. Frankfurt | Espanyol - Estudiantes (LP) |
| Internacional - Dnipro | Internacional - Sassuolo |
| Lazio - Feyenoord | Lazio - Dnipro |
| Melbourne Victory - Leicester City | Melbourne Victory - Eintr. Frankfurt |
| Sunderland - Sassuolo | Sunderland - Real Madrid |
|
| Round 13 (34) | Round 14 (35) |
| Dnipro - Elche | 1.FC Köln - FC Basel |
| Eintr. Frankfurt - Corinthians | Anderlecht - Genoa |
| Estudiantes (LP) - Melbourne Victory | Catania - Dnipro |
| FC Basel - Internacional | Chelsea - Racing Club |
| Feyenoord - 1.FC Köln | Corinthians - Real Madrid |
| Fluminense - Espanyol | Elche - Eintr. Frankfurt |
| Genoa - Sunderland | Espanyol - Leicester City |
| Leicester City - Anderlecht | Internacional - Estudiantes (LP) |
| Racing Club - Lazio | Lazio - Sassuolo |
| Real Madrid - Catania | Melbourne Victory - Feyenoord |
| Sassuolo - Chelsea | Sunderland - Fluminense |
|
| Round 15 (36) | Round 16 (37) |
| Dnipro - Melbourne Victory | 1.FC Köln - Real Madrid |
| Eintr. Frankfurt - Catania | Anderlecht - Feyenoord |
| Estudiantes (LP) - Lazio | Catania - Sassuolo |
| FC Basel - Sunderland | Chelsea - Estudiantes (LP) |
| Feyenoord - Espanyol | Corinthians - Dnipro |
| Fluminense - 1.FC Köln | Elche - Fluminense |
| Genoa - Chelsea | Espanyol - FC Basel |
| Leicester City - Corinthians | Internacional - Genoa |
| Racing Club - Internacional | Lazio - Leicester City |
| Real Madrid - Anderlecht | Melbourne Victory - Racing Club |
| Sassuolo - Elche | Sunderland - Eintr. Frankfurt |
|
| Round 17 (38) | Round 18 (39) |
| 1.FC Köln - Elche | Anderlecht - Dnipro |
| Anderlecht - Estudiantes (LP) | Catania - Espanyol |
| Catania - Melbourne Victory | Corinthians - Elche |
| Corinthians - Racing Club | Eintr. Frankfurt - 1.FC Köln |
| Eintr. Frankfurt - Dnipro | FC Basel - Lazio |
| Espanyol - Lazio | Fluminense - Feyenoord |
| FC Basel - Real Madrid | Genoa - Estudiantes (LP) |
| Fluminense - Sassuolo | Leicester City - Internacional |
| Internacional - Chelsea | Real Madrid - Melbourne Victory |
| Leicester City - Genoa | Sassuolo - Racing Club |
| Sunderland - Feyenoord | Sunderland - Chelsea |
|
| Round 19 (40) | Round 20 (41) |
| 1.FC Köln - Anderlecht | Anderlecht - Espanyol |
| Chelsea - Leicester City | Catania - Internacional |
| Dnipro - Genoa | Corinthians - Melbourne Victory |
| Elche - Real Madrid | Eintr. Frankfurt - Chelsea |
| Espanyol - Corinthians | FC Basel - Estudiantes (LP) |
| Estudiantes (LP) - Sassuolo | Fluminense - Lazio |
| Feyenoord - Eintr. Frankfurt | Genoa - Feyenoord |
| Internacional - Fluminense | Leicester City - Elche |
| Lazio - Sunderland | Real Madrid - Racing Club |
| Melbourne Victory - FC Basel | Sassuolo - Dnipro |
| Racing Club - Catania | Sunderland - 1.FC Köln |
|
| Round 21 (42) |
| 1.FC Köln - Corinthians |
| Chelsea - Catania |
| Dnipro - Real Madrid |
| Elche - FC Basel |
| Espanyol - Sunderland |
| Estudiantes (LP) - Leicester City |
| Feyenoord - Sassuolo |
| Internacional - Anderlecht |
| Lazio - Eintr. Frankfurt |
| Melbourne Victory - Fluminense |
| Racing Club - Genoa |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Anderlecht - Internacional, Catania - Chelsea etc. |