| Round 1 (22) | Round 2 (23) |
| AEK - Paris SG | Barcelona - Genoa |
| Arsenal - Lazio | FC Basel - AEK |
| Bayern München - Flamengo | Flamengo - Roma |
| Celtic - Liverpool | Lazio - Sassuolo |
| Deportivo - Newcastle United | Liverpool - Arsenal |
| Genoa - FC Basel | Manchester City - Celtic |
| Inter - Napoli | Napoli - Deportivo |
| Juventus - Sampdoria | Newcastle United - Juventus |
| Lens - Barcelona | Osasuna - Bayern München |
| Roma - Osasuna | Paris SG - Inter |
| Sassuolo - Manchester City | Sampdoria - Lens |
|
| Round 3 (24) | Round 4 (25) |
| AEK - Barcelona | Barcelona - Deportivo |
| Arsenal - Osasuna | FC Basel - Juventus |
| Bayern München - Manchester City | Flamengo - Sassuolo |
| Celtic - Paris SG | Lazio - Roma |
| Deportivo - Lazio | Liverpool - AEK |
| Genoa - Sampdoria | Manchester City - Arsenal |
| Inter - FC Basel | Napoli - Bayern München |
| Juventus - Liverpool | Newcastle United - Celtic |
| Lens - Flamengo | Osasuna - Genoa |
| Roma - Napoli | Paris SG - Lens |
| Sassuolo - Newcastle United | Sampdoria - Inter |
|
| Round 5 (26) | Round 6 (27) |
| AEK - Flamengo | AEK - Genoa |
| Arsenal - Sampdoria | Arsenal - Bayern München |
| Bayern München - Newcastle United | Barcelona - Paris SG |
| Celtic - FC Basel | Celtic - Inter |
| Deportivo - Paris SG | FC Basel - Sampdoria |
| Genoa - Lazio | Juventus - Deportivo |
| Inter - Barcelona | Lens - Osasuna |
| Juventus - Osasuna | Manchester City - Flamengo |
| Lens - Manchester City | Napoli - Lazio |
| Roma - Liverpool | Newcastle United - Liverpool |
| Sassuolo - Napoli | Roma - Sassuolo |
|
| Round 7 (28) | Round 8 (29) |
| Bayern München - Roma | Barcelona - FC Basel |
| Deportivo - AEK | Bayern München - Inter |
| Flamengo - Newcastle United | Deportivo - Celtic |
| Genoa - Celtic | Flamengo - Osasuna |
| Inter - Juventus | Juventus - AEK |
| Lazio - Lens | Lazio - Liverpool |
| Liverpool - Napoli | Lens - Genoa |
| Osasuna - Manchester City | Manchester City - Paris SG |
| Paris SG - FC Basel | Napoli - Newcastle United |
| Sampdoria - Barcelona | Roma - Arsenal |
| Sassuolo - Arsenal | Sampdoria - Sassuolo |
|
| Round 9 (30) | Round 10 (31) |
| AEK - Lens | Arsenal - Celtic |
| Arsenal - Napoli | Bayern München - AEK |
| Celtic - Juventus | Flamengo - FC Basel |
| FC Basel - Manchester City | Lazio - Sampdoria |
| Genoa - Roma | Liverpool - Paris SG |
| Inter - Deportivo | Manchester City - Barcelona |
| Liverpool - Flamengo | Napoli - Lens |
| Newcastle United - Lazio | Newcastle United - Genoa |
| Osasuna - Barcelona | Osasuna - Inter |
| Paris SG - Sampdoria | Roma - Deportivo |
| Sassuolo - Bayern München | Sassuolo - Juventus |
|
| Round 11 (32) | Round 12 (33) |
| AEK - Lazio | AEK - Osasuna |
| Barcelona - Roma | Barcelona - Bayern München |
| Celtic - Sassuolo | Celtic - Roma |
| Deportivo - Osasuna | Deportivo - Flamengo |
| FC Basel - Liverpool | FC Basel - Lazio |
| Genoa - Napoli | Genoa - Manchester City |
| Inter - Arsenal | Inter - Sassuolo |
| Juventus - Manchester City | Juventus - Arsenal |
| Lens - Bayern München | Lens - Newcastle United |
| Paris SG - Newcastle United | Paris SG - Napoli |
| Sampdoria - Flamengo | Sampdoria - Liverpool |
|
| Round 13 (34) | Round 14 (35) |
| Arsenal - AEK | AEK - Newcastle United |
| Bayern München - Juventus | Barcelona - Liverpool |
| Flamengo - Celtic | Celtic - Lazio |
| Lazio - Paris SG | Deportivo - Sassuolo |
| Liverpool - Genoa | FC Basel - Osasuna |
| Manchester City - Deportivo | Genoa - Arsenal |
| Napoli - FC Basel | Inter - Manchester City |
| Newcastle United - Barcelona | Juventus - Flamengo |
| Osasuna - Sampdoria | Lens - Roma |
| Roma - Inter | Paris SG - Bayern München |
| Sassuolo - Lens | Sampdoria - Napoli |
|
| Round 15 (36) | Round 16 (37) |
| Arsenal - Deportivo | AEK - Manchester City |
| Bayern München - Celtic | Barcelona - Napoli |
| Flamengo - Inter | Celtic - Osasuna |
| Lazio - Barcelona | Deportivo - Bayern München |
| Liverpool - Lens | FC Basel - Roma |
| Manchester City - Sampdoria | Genoa - Flamengo |
| Napoli - AEK | Inter - Liverpool |
| Newcastle United - FC Basel | Juventus - Lazio |
| Osasuna - Paris SG | Lens - Arsenal |
| Roma - Juventus | Paris SG - Sassuolo |
| Sassuolo - Genoa | Sampdoria - Newcastle United |
|
| Round 17 (38) | Round 18 (39) |
| AEK - Sampdoria | Arsenal - FC Basel |
| Arsenal - Flamengo | Bayern München - Genoa |
| Bayern München - Lazio | Celtic - Lens |
| Celtic - Barcelona | Deportivo - Sampdoria |
| Deportivo - Liverpool | Flamengo - Barcelona |
| Genoa - Paris SG | Inter - Lazio |
| Inter - Newcastle United | Juventus - Paris SG |
| Juventus - Napoli | Manchester City - Newcastle United |
| Lens - FC Basel | Osasuna - Napoli |
| Roma - Manchester City | Roma - AEK |
| Sassuolo - Osasuna | Sassuolo - Liverpool |
|
| Round 19 (40) | Round 20 (41) |
| AEK - Sassuolo | Arsenal - Newcastle United |
| Barcelona - Arsenal | Bayern München - Sampdoria |
| FC Basel - Deportivo | Celtic - AEK |
| Genoa - Inter | Deportivo - Genoa |
| Lazio - Manchester City | Flamengo - Napoli |
| Lens - Juventus | Inter - Lens |
| Liverpool - Bayern München | Juventus - Barcelona |
| Napoli - Celtic | Manchester City - Liverpool |
| Newcastle United - Osasuna | Osasuna - Lazio |
| Paris SG - Flamengo | Roma - Paris SG |
| Sampdoria - Roma | Sassuolo - FC Basel |
|
| Round 21 (42) |
| AEK - Inter |
| Barcelona - Sassuolo |
| FC Basel - Bayern München |
| Genoa - Juventus |
| Lazio - Flamengo |
| Lens - Deportivo |
| Liverpool - Osasuna |
| Napoli - Manchester City |
| Newcastle United - Roma |
| Paris SG - Arsenal |
| Sampdoria - Celtic |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Arsenal - Paris SG, Bayern München - FC Basel etc. |