| Round 1 (22) | Round 2 (23) |
| Athletic Bilbao - Lokomotiv | Ajax - Real Madrid |
| Atlético-MG - Marseille | Anderlecht - Valencia |
| Boca Juniors - Shakhtar | Borussia Dortmund - FC Porto |
| Celta Vigo - Ajax | Everton - West Ham United |
| FC Porto - Wolves | Independiente - Atlético-MG |
| Leicester City - Independiente | Lokomotiv - Celta Vigo |
| Lyon - Anderlecht | Marseille - Torino |
| Real Madrid - Monaco | Milan - Lyon |
| Torino - Everton | Monaco - Athletic Bilbao |
| Valencia - Milan | Shakhtar - Leicester City |
| West Ham United - Borussia Dortmund | Wolves - Boca Juniors |
|
| Round 3 (24) | Round 4 (25) |
| Athletic Bilbao - Shakhtar | Ajax - Valencia |
| Atlético-MG - Ajax | Anderlecht - Real Madrid |
| Boca Juniors - Borussia Dortmund | Borussia Dortmund - Atlético-MG |
| Celta Vigo - Milan | Everton - Leicester City |
| FC Porto - Everton | Independiente - Lyon |
| Leicester City - Wolves | Lokomotiv - Boca Juniors |
| Lyon - Monaco | Marseille - Athletic Bilbao |
| Real Madrid - Marseille | Milan - FC Porto |
| Torino - Lokomotiv | Monaco - Celta Vigo |
| Valencia - Independiente | Shakhtar - West Ham United |
| West Ham United - Anderlecht | Wolves - Torino |
|
| Round 5 (26) | Round 6 (27) |
| Athletic Bilbao - Wolves | Athletic Bilbao - Leicester City |
| Atlético-MG - Shakhtar | Boca Juniors - FC Porto |
| Boca Juniors - Anderlecht | Borussia Dortmund - Shakhtar |
| Celta Vigo - Everton | Celta Vigo - Lyon |
| FC Porto - Ajax | Independiente - Ajax |
| Leicester City - Borussia Dortmund | Marseille - Lokomotiv |
| Lyon - Marseille | Monaco - Anderlecht |
| Real Madrid - Independiente | Torino - Atlético-MG |
| Torino - Milan | Valencia - Real Madrid |
| Valencia - Lokomotiv | West Ham United - Milan |
| West Ham United - Monaco | Wolves - Everton |
|
| Round 7 (28) | Round 8 (29) |
| Ajax - West Ham United | Ajax - Lokomotiv |
| Anderlecht - Marseille | Anderlecht - Milan |
| Atlético-MG - Boca Juniors | Atlético-MG - Athletic Bilbao |
| Everton - Borussia Dortmund | Borussia Dortmund - Wolves |
| FC Porto - Athletic Bilbao | Everton - Real Madrid |
| Leicester City - Torino | Independiente - Marseille |
| Lokomotiv - Independiente | Lyon - Leicester City |
| Lyon - Valencia | Monaco - Shakhtar |
| Milan - Monaco | Torino - Boca Juniors |
| Real Madrid - Celta Vigo | Valencia - Celta Vigo |
| Shakhtar - Wolves | West Ham United - FC Porto |
|
| Round 9 (30) | Round 10 (31) |
| Athletic Bilbao - Torino | Ajax - Everton |
| Boca Juniors - West Ham United | Anderlecht - Wolves |
| Celta Vigo - Independiente | Celta Vigo - Athletic Bilbao |
| FC Porto - Valencia | Independiente - West Ham United |
| Leicester City - Atlético-MG | Lokomotiv - Shakhtar |
| Lokomotiv - Anderlecht | Lyon - Boca Juniors |
| Marseille - Ajax | Marseille - FC Porto |
| Milan - Borussia Dortmund | Milan - Leicester City |
| Real Madrid - Lyon | Monaco - Borussia Dortmund |
| Shakhtar - Everton | Real Madrid - Torino |
| Wolves - Monaco | Valencia - Atlético-MG |
|
| Round 11 (32) | Round 12 (33) |
| Athletic Bilbao - Real Madrid | Athletic Bilbao - Valencia |
| Atlético-MG - Milan | Atlético-MG - Anderlecht |
| Boca Juniors - Ajax | Boca Juniors - Milan |
| Borussia Dortmund - Valencia | Borussia Dortmund - Lyon |
| Everton - Anderlecht | Everton - Lokomotiv |
| FC Porto - Independiente | FC Porto - Monaco |
| Leicester City - Celta Vigo | Leicester City - Real Madrid |
| Shakhtar - Marseille | Shakhtar - Independiente |
| Torino - Monaco | Torino - Celta Vigo |
| West Ham United - Lyon | West Ham United - Marseille |
| Wolves - Lokomotiv | Wolves - Ajax |
|
| Round 13 (34) | Round 14 (35) |
| Ajax - Shakhtar | Athletic Bilbao - Ajax |
| Anderlecht - Athletic Bilbao | Atlético-MG - Real Madrid |
| Celta Vigo - Boca Juniors | Boca Juniors - Marseille |
| Independiente - Wolves | Borussia Dortmund - Lokomotiv |
| Lokomotiv - FC Porto | Everton - Independiente |
| Lyon - Torino | FC Porto - Celta Vigo |
| Marseille - Borussia Dortmund | Leicester City - Monaco |
| Milan - Everton | Shakhtar - Lyon |
| Monaco - Atlético-MG | Torino - Anderlecht |
| Real Madrid - West Ham United | West Ham United - Valencia |
| Valencia - Leicester City | Wolves - Milan |
|
| Round 15 (36) | Round 16 (37) |
| Ajax - Borussia Dortmund | Athletic Bilbao - Milan |
| Anderlecht - Leicester City | Atlético-MG - Lyon |
| Celta Vigo - Atlético-MG | Boca Juniors - Monaco |
| Independiente - Boca Juniors | Borussia Dortmund - Independiente |
| Lokomotiv - West Ham United | Everton - Marseille |
| Lyon - Athletic Bilbao | FC Porto - Anderlecht |
| Marseille - Wolves | Leicester City - Lokomotiv |
| Milan - Shakhtar | Shakhtar - Real Madrid |
| Monaco - Everton | Torino - Ajax |
| Real Madrid - FC Porto | West Ham United - Celta Vigo |
| Valencia - Torino | Wolves - Valencia |
|
| Round 17 (38) | Round 18 (39) |
| Athletic Bilbao - Borussia Dortmund | Anderlecht - Borussia Dortmund |
| Atlético-MG - Lokomotiv | Athletic Bilbao - West Ham United |
| Boca Juniors - Everton | Atlético-MG - Everton |
| Celta Vigo - Anderlecht | Celta Vigo - Wolves |
| FC Porto - Shakhtar | Leicester City - Ajax |
| Leicester City - Marseille | Lyon - FC Porto |
| Lyon - Ajax | Milan - Independiente |
| Real Madrid - Milan | Monaco - Marseille |
| Torino - Independiente | Real Madrid - Lokomotiv |
| Valencia - Monaco | Torino - Shakhtar |
| West Ham United - Wolves | Valencia - Boca Juniors |
|
| Round 19 (40) | Round 20 (41) |
| Ajax - Monaco | Anderlecht - Independiente |
| Boca Juniors - Real Madrid | Athletic Bilbao - Boca Juniors |
| Borussia Dortmund - Celta Vigo | Atlético-MG - FC Porto |
| Everton - Valencia | Celta Vigo - Marseille |
| FC Porto - Leicester City | Leicester City - West Ham United |
| Independiente - Athletic Bilbao | Lyon - Everton |
| Lokomotiv - Lyon | Milan - Ajax |
| Marseille - Milan | Monaco - Lokomotiv |
| Shakhtar - Anderlecht | Real Madrid - Wolves |
| West Ham United - Torino | Torino - Borussia Dortmund |
| Wolves - Atlético-MG | Valencia - Shakhtar |
|
| Round 21 (42) |
| Ajax - Anderlecht |
| Boca Juniors - Leicester City |
| Borussia Dortmund - Real Madrid |
| Everton - Athletic Bilbao |
| FC Porto - Torino |
| Independiente - Monaco |
| Lokomotiv - Milan |
| Marseille - Valencia |
| Shakhtar - Celta Vigo |
| West Ham United - Atlético-MG |
| Wolves - Lyon |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Anderlecht - Ajax, Athletic Bilbao - Everton etc. |