| Round 1 (22) | Round 2 (23) |
| Ajax - Napoli | Aston Villa - Bayern München |
| Bayern München - Manchester City | Barcelona - Ajax |
| Boca Juniors - Flamengo | Borussia Dortmund - Manchester United |
| Chelsea - Deportivo | Deportivo - Boca Juniors |
| FC Basel - Paris SG | FC Schalke 04 - FC Porto |
| FC Porto - Lyon | Flamengo - Marseille |
| Feyenoord - FC Schalke 04 | Lyon - Liverpool |
| Liverpool - Borussia Dortmund | Manchester City - Sporting Braga |
| Manchester United - Barcelona | Napoli - FC Basel |
| Marseille - Real Madrid | Paris SG - Feyenoord |
| Sporting Braga - Aston Villa | Real Madrid - Chelsea |
|
| Round 3 (24) | Round 4 (25) |
| Ajax - Deportivo | Aston Villa - Feyenoord |
| Bayern München - Real Madrid | Barcelona - Chelsea |
| Boca Juniors - Aston Villa | Borussia Dortmund - Bayern München |
| Chelsea - Lyon | Deportivo - FC Porto |
| FC Basel - Manchester City | FC Schalke 04 - Ajax |
| FC Porto - Paris SG | Flamengo - Sporting Braga |
| Feyenoord - Napoli | Lyon - FC Basel |
| Liverpool - FC Schalke 04 | Manchester City - Marseille |
| Manchester United - Flamengo | Napoli - Liverpool |
| Marseille - Barcelona | Paris SG - Manchester United |
| Sporting Braga - Borussia Dortmund | Real Madrid - Boca Juniors |
|
| Round 5 (26) | Round 6 (27) |
| Ajax - Aston Villa | Ajax - Manchester United |
| Bayern München - Barcelona | Barcelona - Deportivo |
| Boca Juniors - Napoli | Boca Juniors - Bayern München |
| Chelsea - FC Schalke 04 | Borussia Dortmund - Flamengo |
| FC Basel - Real Madrid | Chelsea - Liverpool |
| FC Porto - Manchester City | FC Basel - Aston Villa |
| Feyenoord - Flamengo | FC Porto - Feyenoord |
| Liverpool - Paris SG | FC Schalke 04 - Napoli |
| Manchester United - Lyon | Paris SG - Lyon |
| Marseille - Borussia Dortmund | Real Madrid - Manchester City |
| Sporting Braga - Deportivo | Sporting Braga - Marseille |
|
| Round 7 (28) | Round 8 (29) |
| Aston Villa - Real Madrid | Ajax - FC Porto |
| Bayern München - Sporting Braga | Bayern München - Liverpool |
| Deportivo - Borussia Dortmund | Borussia Dortmund - Barcelona |
| Feyenoord - Chelsea | FC Basel - Feyenoord |
| Flamengo - FC Basel | Flamengo - Deportivo |
| Liverpool - Ajax | Manchester City - Aston Villa |
| Lyon - FC Schalke 04 | Manchester United - Chelsea |
| Manchester City - Barcelona | Napoli - Marseille |
| Manchester United - FC Porto | Paris SG - FC Schalke 04 |
| Marseille - Boca Juniors | Real Madrid - Lyon |
| Napoli - Paris SG | Sporting Braga - Boca Juniors |
|
| Round 9 (30) | Round 10 (31) |
| Aston Villa - Paris SG | Aston Villa - Liverpool |
| Barcelona - Flamengo | Barcelona - Feyenoord |
| Boca Juniors - Borussia Dortmund | Bayern München - FC Porto |
| Chelsea - Ajax | Boca Juniors - Chelsea |
| Deportivo - Manchester City | Borussia Dortmund - FC Basel |
| FC Porto - FC Basel | Deportivo - Lyon |
| FC Schalke 04 - Real Madrid | Flamengo - Napoli |
| Feyenoord - Sporting Braga | Manchester City - FC Schalke 04 |
| Liverpool - Manchester United | Marseille - Ajax |
| Lyon - Napoli | Real Madrid - Paris SG |
| Marseille - Bayern München | Sporting Braga - Manchester United |
|
| Round 11 (32) | Round 12 (33) |
| Ajax - Real Madrid | Ajax - Boca Juniors |
| Chelsea - Marseille | Chelsea - Sporting Braga |
| FC Basel - Bayern München | FC Basel - Barcelona |
| FC Porto - Flamengo | FC Porto - Aston Villa |
| FC Schalke 04 - Deportivo | FC Schalke 04 - Flamengo |
| Feyenoord - Borussia Dortmund | Feyenoord - Real Madrid |
| Liverpool - Boca Juniors | Liverpool - Marseille |
| Lyon - Barcelona | Lyon - Borussia Dortmund |
| Manchester United - Aston Villa | Manchester United - Manchester City |
| Napoli - Manchester City | Napoli - Deportivo |
| Paris SG - Sporting Braga | Paris SG - Bayern München |
|
| Round 13 (34) | Round 14 (35) |
| Aston Villa - Napoli | Ajax - Manchester City |
| Barcelona - Paris SG | Chelsea - Flamengo |
| Bayern München - Ajax | FC Basel - Sporting Braga |
| Boca Juniors - FC Porto | FC Porto - Barcelona |
| Borussia Dortmund - FC Schalke 04 | FC Schalke 04 - Aston Villa |
| Deportivo - Feyenoord | Feyenoord - Boca Juniors |
| Flamengo - Lyon | Liverpool - Real Madrid |
| Manchester City - Chelsea | Lyon - Bayern München |
| Marseille - FC Basel | Manchester United - Marseille |
| Real Madrid - Manchester United | Napoli - Borussia Dortmund |
| Sporting Braga - Liverpool | Paris SG - Deportivo |
|
| Round 15 (36) | Round 16 (37) |
| Aston Villa - Lyon | Ajax - Flamengo |
| Barcelona - FC Schalke 04 | Chelsea - Aston Villa |
| Bayern München - Chelsea | FC Basel - Boca Juniors |
| Boca Juniors - Manchester United | FC Porto - Real Madrid |
| Borussia Dortmund - FC Porto | FC Schalke 04 - Sporting Braga |
| Deportivo - FC Basel | Feyenoord - Manchester City |
| Flamengo - Paris SG | Liverpool - Deportivo |
| Manchester City - Liverpool | Lyon - Marseille |
| Marseille - Feyenoord | Manchester United - Bayern München |
| Real Madrid - Napoli | Napoli - Barcelona |
| Sporting Braga - Ajax | Paris SG - Borussia Dortmund |
|
| Round 17 (38) | Round 18 (39) |
| Ajax - Borussia Dortmund | Ajax - Lyon |
| Bayern München - Flamengo | Aston Villa - Borussia Dortmund |
| Boca Juniors - Manchester City | Bayern München - Feyenoord |
| Chelsea - Paris SG | Boca Juniors - FC Schalke 04 |
| FC Basel - FC Schalke 04 | Chelsea - FC Basel |
| FC Porto - Napoli | Liverpool - Flamengo |
| Feyenoord - Lyon | Manchester City - Paris SG |
| Liverpool - Barcelona | Manchester United - Napoli |
| Manchester United - Deportivo | Marseille - Deportivo |
| Marseille - Aston Villa | Real Madrid - Barcelona |
| Sporting Braga - Real Madrid | Sporting Braga - FC Porto |
|
| Round 19 (40) | Round 20 (41) |
| Barcelona - Aston Villa | Ajax - Paris SG |
| Borussia Dortmund - Chelsea | Aston Villa - Flamengo |
| Deportivo - Bayern München | Bayern München - Napoli |
| FC Basel - Ajax | Boca Juniors - Barcelona |
| FC Porto - Marseille | Chelsea - FC Porto |
| FC Schalke 04 - Manchester United | Liverpool - FC Basel |
| Feyenoord - Liverpool | Manchester City - Borussia Dortmund |
| Flamengo - Real Madrid | Manchester United - Feyenoord |
| Lyon - Manchester City | Marseille - FC Schalke 04 |
| Napoli - Sporting Braga | Real Madrid - Deportivo |
| Paris SG - Boca Juniors | Sporting Braga - Lyon |
|
| Round 21 (42) |
| Barcelona - Sporting Braga |
| Borussia Dortmund - Real Madrid |
| Deportivo - Aston Villa |
| FC Basel - Manchester United |
| FC Porto - Liverpool |
| FC Schalke 04 - Bayern München |
| Feyenoord - Ajax |
| Flamengo - Manchester City |
| Lyon - Boca Juniors |
| Napoli - Chelsea |
| Paris SG - Marseille |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Ajax - Feyenoord, Aston Villa - Deportivo etc. |