| Round 1 (22) | Round 2 (23) |
| Aberdeen - Independiente | Atalanta - Aberdeen |
| Benfica - Real Betis | Bayer Leverkusen - Spartak |
| FC Augsburg - Newcastle United | Fenerbahçe - Sevilla |
| FC Twente - Atalanta | Independiente - RB Leipzig |
| Lokomotiv - West Ham United | Inter - Benfica |
| Milan - Rangers | Newcastle United - Milan |
| RB Leipzig - Bayer Leverkusen | Rangers - Real Sociedad |
| Real Sociedad - Tottenham Hotspur | Real Betis - Strasbourg |
| Sevilla - Valencia | Tottenham Hotspur - FC Augsburg |
| Spartak - Fenerbahçe | Valencia - Lokomotiv |
| Strasbourg - Inter | West Ham United - FC Twente |
|
| Round 3 (24) | Round 4 (25) |
| Aberdeen - Inter | Atalanta - Sevilla |
| Benfica - Valencia | Bayer Leverkusen - FC Twente |
| FC Augsburg - West Ham United | Fenerbahçe - Aberdeen |
| FC Twente - Rangers | Independiente - Lokomotiv |
| Lokomotiv - Tottenham Hotspur | Inter - FC Augsburg |
| Milan - Fenerbahçe | Newcastle United - Real Sociedad |
| RB Leipzig - Atalanta | Rangers - Spartak |
| Real Sociedad - Real Betis | Real Betis - RB Leipzig |
| Sevilla - Bayer Leverkusen | Tottenham Hotspur - Benfica |
| Spartak - Independiente | Valencia - Strasbourg |
| Strasbourg - Newcastle United | West Ham United - Milan |
|
| Round 5 (26) | Round 6 (27) |
| Aberdeen - Newcastle United | Aberdeen - Real Betis |
| Benfica - Rangers | Bayer Leverkusen - Atalanta |
| FC Augsburg - Valencia | Benfica - FC Augsburg |
| FC Twente - Real Betis | FC Twente - Lokomotiv |
| Lokomotiv - Fenerbahçe | Independiente - Fenerbahçe |
| Milan - Bayer Leverkusen | Milan - Sevilla |
| RB Leipzig - Tottenham Hotspur | Newcastle United - Inter |
| Real Sociedad - Atalanta | Real Sociedad - Strasbourg |
| Sevilla - Independiente | Spartak - RB Leipzig |
| Spartak - Inter | Valencia - Tottenham Hotspur |
| Strasbourg - West Ham United | West Ham United - Rangers |
|
| Round 7 (28) | Round 8 (29) |
| Atalanta - Independiente | Aberdeen - RB Leipzig |
| FC Augsburg - Real Sociedad | Atalanta - FC Augsburg |
| Fenerbahçe - Bayer Leverkusen | Benfica - Real Sociedad |
| Inter - West Ham United | FC Twente - Spartak |
| Lokomotiv - Spartak | Independiente - Bayer Leverkusen |
| RB Leipzig - Milan | Inter - Real Betis |
| Rangers - Valencia | Lokomotiv - Milan |
| Real Betis - Newcastle United | Newcastle United - Fenerbahçe |
| Sevilla - FC Twente | Strasbourg - Sevilla |
| Strasbourg - Benfica | Tottenham Hotspur - Rangers |
| Tottenham Hotspur - Aberdeen | Valencia - West Ham United |
|
| Round 9 (30) | Round 10 (31) |
| Bayer Leverkusen - Newcastle United | Benfica - Lokomotiv |
| FC Augsburg - Strasbourg | FC Augsburg - FC Twente |
| Fenerbahçe - Atalanta | Inter - Bayer Leverkusen |
| Milan - FC Twente | Newcastle United - Independiente |
| RB Leipzig - Benfica | Rangers - Fenerbahçe |
| Rangers - Inter | Real Betis - Sevilla |
| Real Betis - Independiente | Real Sociedad - Milan |
| Real Sociedad - Valencia | Strasbourg - Spartak |
| Sevilla - Lokomotiv | Tottenham Hotspur - Atalanta |
| Spartak - Aberdeen | Valencia - Aberdeen |
| West Ham United - Tottenham Hotspur | West Ham United - RB Leipzig |
|
| Round 11 (32) | Round 12 (33) |
| Aberdeen - Strasbourg | Aberdeen - West Ham United |
| Atalanta - Inter | Atalanta - Rangers |
| Bayer Leverkusen - Rangers | Bayer Leverkusen - Tottenham Hotspur |
| FC Twente - Newcastle United | FC Twente - Real Sociedad |
| Fenerbahçe - West Ham United | Fenerbahçe - Valencia |
| Independiente - Benfica | Independiente - Strasbourg |
| Lokomotiv - Real Betis | Lokomotiv - Inter |
| Milan - FC Augsburg | Milan - Benfica |
| RB Leipzig - Valencia | RB Leipzig - Newcastle United |
| Sevilla - Real Sociedad | Sevilla - FC Augsburg |
| Spartak - Tottenham Hotspur | Spartak - Real Betis |
|
| Round 13 (34) | Round 14 (35) |
| Benfica - Sevilla | Aberdeen - Benfica |
| FC Augsburg - Aberdeen | Atalanta - Valencia |
| Inter - Milan | Bayer Leverkusen - Real Betis |
| Newcastle United - Lokomotiv | FC Twente - Inter |
| Rangers - RB Leipzig | Fenerbahçe - Strasbourg |
| Real Betis - Atalanta | Independiente - Rangers |
| Real Sociedad - Spartak | Lokomotiv - FC Augsburg |
| Strasbourg - FC Twente | Milan - Tottenham Hotspur |
| Tottenham Hotspur - Fenerbahçe | RB Leipzig - Real Sociedad |
| Valencia - Bayer Leverkusen | Sevilla - Newcastle United |
| West Ham United - Independiente | Spartak - West Ham United |
|
| Round 15 (36) | Round 16 (37) |
| Benfica - FC Twente | Aberdeen - Real Sociedad |
| FC Augsburg - RB Leipzig | Atalanta - West Ham United |
| Inter - Sevilla | Bayer Leverkusen - Benfica |
| Newcastle United - Atalanta | FC Twente - Tottenham Hotspur |
| Rangers - Aberdeen | Fenerbahçe - FC Augsburg |
| Real Betis - Fenerbahçe | Independiente - Valencia |
| Real Sociedad - Lokomotiv | Lokomotiv - Strasbourg |
| Strasbourg - Milan | Milan - Real Betis |
| Tottenham Hotspur - Independiente | RB Leipzig - Inter |
| Valencia - Spartak | Sevilla - Rangers |
| West Ham United - Bayer Leverkusen | Spartak - Newcastle United |
|
| Round 17 (38) | Round 18 (39) |
| Aberdeen - Bayer Leverkusen | Benfica - Spartak |
| Benfica - Newcastle United | FC Augsburg - Rangers |
| FC Augsburg - Real Betis | FC Twente - Fenerbahçe |
| FC Twente - Valencia | Inter - Independiente |
| Lokomotiv - Rangers | Lokomotiv - Atalanta |
| Milan - Independiente | Milan - Aberdeen |
| RB Leipzig - Fenerbahçe | Newcastle United - West Ham United |
| Real Sociedad - Inter | Real Betis - Valencia |
| Sevilla - West Ham United | Real Sociedad - Bayer Leverkusen |
| Spartak - Atalanta | Sevilla - Tottenham Hotspur |
| Strasbourg - Tottenham Hotspur | Strasbourg - RB Leipzig |
|
| Round 19 (40) | Round 20 (41) |
| Aberdeen - FC Twente | Benfica - Fenerbahçe |
| Atalanta - Benfica | FC Augsburg - Bayer Leverkusen |
| Bayer Leverkusen - Lokomotiv | FC Twente - Independiente |
| Fenerbahçe - Inter | Inter - Valencia |
| Independiente - Real Sociedad | Lokomotiv - RB Leipzig |
| RB Leipzig - Sevilla | Milan - Spartak |
| Rangers - Strasbourg | Newcastle United - Rangers |
| Spartak - FC Augsburg | Real Betis - Tottenham Hotspur |
| Tottenham Hotspur - Newcastle United | Real Sociedad - West Ham United |
| Valencia - Milan | Sevilla - Aberdeen |
| West Ham United - Real Betis | Strasbourg - Atalanta |
|
| Round 21 (42) |
| Aberdeen - Lokomotiv |
| Atalanta - Milan |
| Bayer Leverkusen - Strasbourg |
| Fenerbahçe - Real Sociedad |
| Independiente - FC Augsburg |
| RB Leipzig - FC Twente |
| Rangers - Real Betis |
| Spartak - Sevilla |
| Tottenham Hotspur - Inter |
| Valencia - Newcastle United |
| West Ham United - Benfica |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Benfica - West Ham United, FC Augsburg - Independiente etc. |