| Round 1 (22) | Round 2 (23) |
| Ajax - FC Schalke 04 | Bayern München - Aston Villa |
| Aston Villa - Borussia Dortmund | Borussia Dortmund - Ajax |
| Barcelona - Real Madrid | FC Porto - Independiente |
| Bayer Leverkusen - Bayern München | FC Schalke 04 - Marseille |
| Boca Juniors - Lyon | Flamengo - Bayer Leverkusen |
| Deportivo - FC Porto | Liverpool - Deportivo |
| Feyenoord - Paris SG | Lyon - Newcastle United |
| Independiente - Liverpool | Paris SG - Boca Juniors |
| Manchester City - Flamengo | RB Leipzig - Feyenoord |
| Marseille - Sporting Braga | Real Madrid - Manchester City |
| Newcastle United - RB Leipzig | Sporting Braga - Barcelona |
|
| Round 3 (24) | Round 4 (25) |
| Ajax - Liverpool | Bayern München - Boca Juniors |
| Aston Villa - Lyon | Borussia Dortmund - Manchester City |
| Barcelona - FC Schalke 04 | FC Porto - Marseille |
| Bayer Leverkusen - RB Leipzig | FC Schalke 04 - Bayer Leverkusen |
| Boca Juniors - Real Madrid | Flamengo - Independiente |
| Deportivo - Flamengo | Liverpool - Feyenoord |
| Feyenoord - Bayern München | Lyon - Barcelona |
| Independiente - Paris SG | Paris SG - Newcastle United |
| Manchester City - Sporting Braga | RB Leipzig - Deportivo |
| Marseille - Borussia Dortmund | Real Madrid - Ajax |
| Newcastle United - FC Porto | Sporting Braga - Aston Villa |
|
| Round 5 (26) | Round 6 (27) |
| Ajax - Paris SG | Ajax - FC Porto |
| Aston Villa - FC Porto | Aston Villa - Bayer Leverkusen |
| Barcelona - Liverpool | Barcelona - Marseille |
| Bayer Leverkusen - Real Madrid | Bayern München - Lyon |
| Boca Juniors - Sporting Braga | Boca Juniors - Manchester City |
| Deportivo - Lyon | Deportivo - Feyenoord |
| Feyenoord - Flamengo | FC Schalke 04 - Real Madrid |
| Independiente - Bayern München | Flamengo - RB Leipzig |
| Manchester City - FC Schalke 04 | Newcastle United - Independiente |
| Marseille - RB Leipzig | Paris SG - Liverpool |
| Newcastle United - Borussia Dortmund | Sporting Braga - Borussia Dortmund |
|
| Round 7 (28) | Round 8 (29) |
| Bayer Leverkusen - Barcelona | Ajax - Marseille |
| Borussia Dortmund - FC Schalke 04 | Aston Villa - Barcelona |
| FC Porto - Paris SG | Bayer Leverkusen - Boca Juniors |
| Feyenoord - Newcastle United | Borussia Dortmund - Feyenoord |
| Independiente - Deportivo | Deportivo - Newcastle United |
| Liverpool - Bayern München | FC Schalke 04 - Sporting Braga |
| Lyon - Flamengo | Flamengo - Bayern München |
| Manchester City - Aston Villa | Independiente - Manchester City |
| Marseille - Boca Juniors | Liverpool - FC Porto |
| RB Leipzig - Ajax | Paris SG - Real Madrid |
| Real Madrid - Sporting Braga | RB Leipzig - Lyon |
|
| Round 9 (30) | Round 10 (31) |
| Barcelona - Ajax | Bayern München - Marseille |
| Bayern München - RB Leipzig | Deportivo - Bayer Leverkusen |
| Boca Juniors - Aston Villa | FC Porto - Manchester City |
| FC Porto - FC Schalke 04 | Feyenoord - Aston Villa |
| Feyenoord - Independiente | Flamengo - Ajax |
| Lyon - Liverpool | Independiente - Barcelona |
| Manchester City - Bayer Leverkusen | Liverpool - Sporting Braga |
| Marseille - Deportivo | Lyon - Real Madrid |
| Newcastle United - Flamengo | Newcastle United - Boca Juniors |
| Real Madrid - Borussia Dortmund | Paris SG - FC Schalke 04 |
| Sporting Braga - Paris SG | RB Leipzig - Borussia Dortmund |
|
| Round 11 (32) | Round 12 (33) |
| Ajax - Independiente | Ajax - Bayern München |
| Aston Villa - Paris SG | Aston Villa - Newcastle United |
| Barcelona - RB Leipzig | Barcelona - FC Porto |
| Bayer Leverkusen - FC Porto | Bayer Leverkusen - Liverpool |
| Boca Juniors - Feyenoord | Boca Juniors - Deportivo |
| Borussia Dortmund - Liverpool | Borussia Dortmund - Lyon |
| FC Schalke 04 - Deportivo | FC Schalke 04 - Independiente |
| Manchester City - Newcastle United | Manchester City - Feyenoord |
| Marseille - Flamengo | Marseille - Paris SG |
| Real Madrid - Bayern München | Real Madrid - Flamengo |
| Sporting Braga - Lyon | Sporting Braga - RB Leipzig |
|
| Round 13 (34) | Round 14 (35) |
| Bayern München - FC Schalke 04 | Ajax - Deportivo |
| Deportivo - Manchester City | Aston Villa - Liverpool |
| FC Porto - Borussia Dortmund | Barcelona - Bayern München |
| Feyenoord - Ajax | Bayer Leverkusen - Feyenoord |
| Flamengo - Sporting Braga | Boca Juniors - RB Leipzig |
| Independiente - Aston Villa | Borussia Dortmund - Flamengo |
| Liverpool - Boca Juniors | FC Schalke 04 - Lyon |
| Lyon - Marseille | Manchester City - Paris SG |
| Newcastle United - Barcelona | Marseille - Newcastle United |
| Paris SG - Bayer Leverkusen | Real Madrid - Independiente |
| RB Leipzig - Real Madrid | Sporting Braga - FC Porto |
|
| Round 15 (36) | Round 16 (37) |
| Bayern München - Sporting Braga | Ajax - Newcastle United |
| Deportivo - Aston Villa | Aston Villa - RB Leipzig |
| FC Porto - Real Madrid | Barcelona - Paris SG |
| Feyenoord - Marseille | Bayer Leverkusen - Independiente |
| Flamengo - Barcelona | Boca Juniors - FC Porto |
| Independiente - Boca Juniors | Borussia Dortmund - Bayern München |
| Liverpool - Manchester City | FC Schalke 04 - Flamengo |
| Lyon - Ajax | Manchester City - Lyon |
| Newcastle United - Bayer Leverkusen | Marseille - Liverpool |
| Paris SG - Borussia Dortmund | Real Madrid - Feyenoord |
| RB Leipzig - FC Schalke 04 | Sporting Braga - Deportivo |
|
| Round 17 (38) | Round 18 (39) |
| Ajax - Sporting Braga | Aston Villa - Real Madrid |
| Aston Villa - Flamengo | Bayer Leverkusen - Borussia Dortmund |
| Barcelona - Borussia Dortmund | Boca Juniors - Ajax |
| Bayer Leverkusen - Lyon | Deportivo - Barcelona |
| Boca Juniors - FC Schalke 04 | FC Porto - Flamengo |
| Deportivo - Paris SG | Feyenoord - Lyon |
| Feyenoord - FC Porto | Independiente - Marseille |
| Independiente - RB Leipzig | Liverpool - FC Schalke 04 |
| Manchester City - Bayern München | Manchester City - RB Leipzig |
| Marseille - Real Madrid | Newcastle United - Sporting Braga |
| Newcastle United - Liverpool | Paris SG - Bayern München |
|
| Round 19 (40) | Round 20 (41) |
| Ajax - Aston Villa | Aston Villa - FC Schalke 04 |
| Barcelona - Feyenoord | Bayer Leverkusen - Marseille |
| Bayern München - FC Porto | Boca Juniors - Barcelona |
| Borussia Dortmund - Deportivo | Deportivo - Real Madrid |
| FC Schalke 04 - Newcastle United | FC Porto - RB Leipzig |
| Flamengo - Boca Juniors | Feyenoord - Sporting Braga |
| Lyon - Independiente | Independiente - Borussia Dortmund |
| Marseille - Manchester City | Liverpool - Flamengo |
| RB Leipzig - Paris SG | Manchester City - Ajax |
| Real Madrid - Liverpool | Newcastle United - Bayern München |
| Sporting Braga - Bayer Leverkusen | Paris SG - Lyon |
|
| Round 21 (42) |
| Ajax - Bayer Leverkusen |
| Barcelona - Manchester City |
| Bayern München - Deportivo |
| Borussia Dortmund - Boca Juniors |
| FC Schalke 04 - Feyenoord |
| Flamengo - Paris SG |
| Lyon - FC Porto |
| Marseille - Aston Villa |
| RB Leipzig - Liverpool |
| Real Madrid - Newcastle United |
| Sporting Braga - Independiente |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Aston Villa - Marseille, Bayer Leverkusen - Ajax etc. |