| Round 1 (22) | Round 2 (23) |
| Chelsea - B.Mönchengladbach | Arsenal - Milan |
| Fiorentina - Rangers | Atalanta - Fiorentina |
| Inter - FC Twente | B.Mönchengladbach - Sevilla |
| Milan - VfB Stuttgart | FC Twente - Sporting |
| Sevilla - Atalanta | Fenerbahçe - Strasbourg |
| Sporting - Arsenal | Manchester United - Inter |
| Strasbourg - Napoli | Napoli - Tottenham Hotspur |
| Tottenham Hotspur - Manchester United | Rangers - Chelsea |
| Valencia - Real Betis | Real Betis - Villarreal |
| Villarreal - Spartak | Spartak - Valencia |
| West Ham United - Fenerbahçe | VfB Stuttgart - West Ham United |
|
| Round 3 (24) | Round 4 (25) |
| Chelsea - Manchester United | Arsenal - Chelsea |
| Fiorentina - Arsenal | Atalanta - Villarreal |
| Inter - Napoli | B.Mönchengladbach - Tottenham Hotspur |
| Milan - B.Mönchengladbach | FC Twente - Valencia |
| Sevilla - Spartak | Fenerbahçe - Sporting |
| Sporting - Atalanta | Manchester United - West Ham United |
| Strasbourg - VfB Stuttgart | Napoli - Milan |
| Tottenham Hotspur - Fenerbahçe | Rangers - Sevilla |
| Valencia - Rangers | Real Betis - Fiorentina |
| Villarreal - FC Twente | Spartak - Strasbourg |
| West Ham United - Real Betis | VfB Stuttgart - Inter |
|
| Round 5 (26) | Round 6 (27) |
| Chelsea - Napoli | Arsenal - B.Mönchengladbach |
| Fiorentina - FC Twente | Chelsea - Inter |
| Inter - Fenerbahçe | FC Twente - Atalanta |
| Milan - Spartak | Fenerbahçe - Manchester United |
| Sevilla - VfB Stuttgart | Milan - Sporting |
| Sporting - Manchester United | Napoli - VfB Stuttgart |
| Strasbourg - Atalanta | Rangers - Real Betis |
| Tottenham Hotspur - Real Betis | Sevilla - Valencia |
| Valencia - Arsenal | Tottenham Hotspur - Strasbourg |
| Villarreal - B.Mönchengladbach | Villarreal - Fiorentina |
| West Ham United - Rangers | West Ham United - Spartak |
|
| Round 7 (28) | Round 8 (29) |
| Atalanta - West Ham United | Atalanta - B.Mönchengladbach |
| B.Mönchengladbach - FC Twente | FC Twente - Arsenal |
| Fiorentina - Sevilla | Fenerbahçe - Napoli |
| Inter - Milan | Milan - Tottenham Hotspur |
| Manchester United - Napoli | Rangers - Manchester United |
| Real Betis - Arsenal | Real Betis - Spartak |
| Spartak - Rangers | Sporting - Chelsea |
| Sporting - Tottenham Hotspur | Valencia - Inter |
| Strasbourg - Chelsea | VfB Stuttgart - Fiorentina |
| Valencia - Villarreal | Villarreal - Sevilla |
| VfB Stuttgart - Fenerbahçe | West Ham United - Strasbourg |
|
| Round 9 (30) | Round 10 (31) |
| Arsenal - Atalanta | Arsenal - Strasbourg |
| B.Mönchengladbach - Real Betis | Atalanta - VfB Stuttgart |
| Chelsea - Milan | B.Mönchengladbach - Manchester United |
| Fiorentina - Valencia | FC Twente - West Ham United |
| Inter - Sporting | Fiorentina - Milan |
| Manchester United - VfB Stuttgart | Rangers - Fenerbahçe |
| Napoli - Rangers | Real Betis - Napoli |
| Sevilla - FC Twente | Sevilla - Chelsea |
| Spartak - Fenerbahçe | Spartak - Inter |
| Strasbourg - Villarreal | Valencia - Tottenham Hotspur |
| Tottenham Hotspur - West Ham United | Villarreal - Sporting |
|
| Round 11 (32) | Round 12 (33) |
| Chelsea - Fiorentina | Chelsea - Villarreal |
| Fenerbahçe - Villarreal | Fenerbahçe - Valencia |
| Inter - Sevilla | Inter - Fiorentina |
| Manchester United - Arsenal | Manchester United - FC Twente |
| Milan - Rangers | Milan - Sevilla |
| Napoli - B.Mönchengladbach | Napoli - Atalanta |
| Sporting - Spartak | Sporting - Real Betis |
| Strasbourg - FC Twente | Strasbourg - Rangers |
| Tottenham Hotspur - Atalanta | Tottenham Hotspur - Spartak |
| VfB Stuttgart - Real Betis | VfB Stuttgart - B.Mönchengladbach |
| West Ham United - Valencia | West Ham United - Arsenal |
|
| Round 13 (34) | Round 14 (35) |
| Arsenal - Fenerbahçe | Chelsea - Atalanta |
| Atalanta - Manchester United | Fenerbahçe - B.Mönchengladbach |
| B.Mönchengladbach - Strasbourg | Inter - Rangers |
| FC Twente - Napoli | Manchester United - Valencia |
| Fiorentina - West Ham United | Milan - Real Betis |
| Rangers - Sporting | Napoli - Spartak |
| Real Betis - Chelsea | Sporting - Fiorentina |
| Sevilla - Tottenham Hotspur | Strasbourg - Sevilla |
| Spartak - VfB Stuttgart | Tottenham Hotspur - Arsenal |
| Valencia - Milan | VfB Stuttgart - FC Twente |
| Villarreal - Inter | West Ham United - Villarreal |
|
| Round 15 (36) | Round 16 (37) |
| Arsenal - Napoli | Chelsea - Spartak |
| Atalanta - Fenerbahçe | Fenerbahçe - FC Twente |
| B.Mönchengladbach - West Ham United | Inter - B.Mönchengladbach |
| FC Twente - Tottenham Hotspur | Manchester United - Fiorentina |
| Fiorentina - Strasbourg | Milan - Atalanta |
| Rangers - VfB Stuttgart | Napoli - Villarreal |
| Real Betis - Inter | Sporting - Valencia |
| Sevilla - Sporting | Strasbourg - Real Betis |
| Spartak - Manchester United | Tottenham Hotspur - Rangers |
| Valencia - Chelsea | VfB Stuttgart - Arsenal |
| Villarreal - Milan | West Ham United - Sevilla |
|
| Round 17 (38) | Round 18 (39) |
| Chelsea - Fenerbahçe | Chelsea - West Ham United |
| Fiorentina - Spartak | Fiorentina - B.Mönchengladbach |
| Inter - Arsenal | Inter - Atalanta |
| Milan - FC Twente | Milan - Manchester United |
| Sevilla - Real Betis | Rangers - Arsenal |
| Sporting - B.Mönchengladbach | Real Betis - Fenerbahçe |
| Strasbourg - Manchester United | Sevilla - Napoli |
| Tottenham Hotspur - VfB Stuttgart | Spartak - FC Twente |
| Valencia - Atalanta | Sporting - VfB Stuttgart |
| Villarreal - Rangers | Valencia - Strasbourg |
| West Ham United - Napoli | Villarreal - Tottenham Hotspur |
|
| Round 19 (40) | Round 20 (41) |
| Arsenal - Spartak | Chelsea - Tottenham Hotspur |
| Atalanta - Rangers | Fiorentina - Napoli |
| B.Mönchengladbach - Valencia | Inter - West Ham United |
| FC Twente - Chelsea | Milan - Fenerbahçe |
| Fenerbahçe - Sevilla | Rangers - B.Mönchengladbach |
| Manchester United - Real Betis | Real Betis - FC Twente |
| Napoli - Sporting | Sevilla - Arsenal |
| Strasbourg - Inter | Spartak - Atalanta |
| Tottenham Hotspur - Fiorentina | Sporting - Strasbourg |
| VfB Stuttgart - Villarreal | Valencia - VfB Stuttgart |
| West Ham United - Milan | Villarreal - Manchester United |
|
| Round 21 (42) |
| Arsenal - Villarreal |
| Atalanta - Real Betis |
| B.Mönchengladbach - Spartak |
| FC Twente - Rangers |
| Fenerbahçe - Fiorentina |
| Manchester United - Sevilla |
| Napoli - Valencia |
| Strasbourg - Milan |
| Tottenham Hotspur - Inter |
| VfB Stuttgart - Chelsea |
| West Ham United - Sporting |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Chelsea - VfB Stuttgart, Fiorentina - Fenerbahçe etc. |