| Round 1 (22) | Round 2 (23) |
| Arsenal - Fiorentina | B.Mönchengladbach - Arsenal |
| Aston Villa - Manchester City | Dundee United - Chelsea |
| Atalanta - Villarreal | FC Porto - Torino |
| Chelsea - B.Mönchengladbach | Fiorentina - Sporting |
| FC Twente - Tottenham Hotspur | Manchester City - RB Leipzig |
| Lille - Sevilla | Sevilla - Sassuolo |
| Napoli - Spartak | Spartak - FC Twente |
| RB Leipzig - VfB Stuttgart | Tottenham Hotspur - Napoli |
| Sassuolo - FC Porto | Valencia - Aston Villa |
| Sporting - Dundee United | VfB Stuttgart - Atalanta |
| Torino - Valencia | Villarreal - Lille |
|
| Round 3 (24) | Round 4 (25) |
| Arsenal - Sevilla | B.Mönchengladbach - Napoli |
| Aston Villa - FC Porto | Dundee United - RB Leipzig |
| Atalanta - Manchester City | FC Porto - Atalanta |
| Chelsea - Spartak | Fiorentina - Chelsea |
| FC Twente - Fiorentina | Manchester City - Sassuolo |
| Lille - B.Mönchengladbach | Sevilla - Sporting |
| Napoli - Villarreal | Spartak - Aston Villa |
| RB Leipzig - Valencia | Tottenham Hotspur - Arsenal |
| Sassuolo - Dundee United | Valencia - Lille |
| Sporting - VfB Stuttgart | VfB Stuttgart - Torino |
| Torino - Tottenham Hotspur | Villarreal - FC Twente |
|
| Round 5 (26) | Round 6 (27) |
| Arsenal - Villarreal | Chelsea - FC Twente |
| Aston Villa - B.Mönchengladbach | Fiorentina - Tottenham Hotspur |
| Atalanta - Valencia | Manchester City - FC Porto |
| Chelsea - FC Porto | Napoli - Arsenal |
| FC Twente - Sevilla | RB Leipzig - Aston Villa |
| Lille - VfB Stuttgart | Sassuolo - Lille |
| Napoli - Dundee United | Sevilla - Dundee United |
| RB Leipzig - Tottenham Hotspur | Sporting - Atalanta |
| Sassuolo - Spartak | Torino - Spartak |
| Sporting - Manchester City | Valencia - VfB Stuttgart |
| Torino - Fiorentina | Villarreal - B.Mönchengladbach |
|
| Round 7 (28) | Round 8 (29) |
| Arsenal - Chelsea | B.Mönchengladbach - Dundee United |
| Aston Villa - Sporting | FC Porto - Arsenal |
| Atalanta - Sassuolo | FC Twente - Atalanta |
| B.Mönchengladbach - Torino | Fiorentina - VfB Stuttgart |
| Dundee United - Villarreal | Lille - Sporting |
| FC Porto - Valencia | Napoli - Chelsea |
| FC Twente - Napoli | Sassuolo - RB Leipzig |
| Lille - RB Leipzig | Torino - Aston Villa |
| Spartak - Fiorentina | Tottenham Hotspur - Spartak |
| Tottenham Hotspur - Sevilla | Valencia - Manchester City |
| VfB Stuttgart - Manchester City | Villarreal - Sevilla |
|
| Round 9 (30) | Round 10 (31) |
| Arsenal - FC Twente | Arsenal - Sassuolo |
| Aston Villa - Napoli | B.Mönchengladbach - FC Porto |
| Atalanta - Lille | Chelsea - Sporting |
| Chelsea - Villarreal | Dundee United - VfB Stuttgart |
| Dundee United - Tottenham Hotspur | FC Twente - RB Leipzig |
| Manchester City - Fiorentina | Fiorentina - Valencia |
| RB Leipzig - Torino | Napoli - Lille |
| Sevilla - B.Mönchengladbach | Sevilla - Aston Villa |
| Spartak - Valencia | Spartak - Atalanta |
| Sporting - Sassuolo | Tottenham Hotspur - Manchester City |
| VfB Stuttgart - FC Porto | Villarreal - Torino |
|
| Round 11 (32) | Round 12 (33) |
| Aston Villa - Villarreal | Aston Villa - Fiorentina |
| Atalanta - Chelsea | Atalanta - Arsenal |
| FC Porto - Tottenham Hotspur | FC Porto - Dundee United |
| Lille - Spartak | Lille - Tottenham Hotspur |
| Manchester City - Dundee United | Manchester City - B.Mönchengladbach |
| RB Leipzig - B.Mönchengladbach | RB Leipzig - Spartak |
| Sassuolo - Fiorentina | Sassuolo - Chelsea |
| Sporting - Arsenal | Sporting - Napoli |
| Torino - FC Twente | Torino - Sevilla |
| Valencia - Napoli | Valencia - FC Twente |
| VfB Stuttgart - Sevilla | VfB Stuttgart - Villarreal |
|
| Round 13 (34) | Round 14 (35) |
| Arsenal - Torino | Aston Villa - Chelsea |
| B.Mönchengladbach - VfB Stuttgart | Atalanta - Fiorentina |
| Chelsea - RB Leipzig | FC Porto - Villarreal |
| Dundee United - Aston Villa | Lille - Arsenal |
| FC Twente - Sassuolo | Manchester City - Spartak |
| Fiorentina - Lille | RB Leipzig - Sevilla |
| Napoli - Atalanta | Sassuolo - Tottenham Hotspur |
| Sevilla - Valencia | Sporting - B.Mönchengladbach |
| Spartak - FC Porto | Torino - Napoli |
| Tottenham Hotspur - Sporting | Valencia - Dundee United |
| Villarreal - Manchester City | VfB Stuttgart - FC Twente |
|
| Round 15 (36) | Round 16 (37) |
| Arsenal - Aston Villa | Aston Villa - Tottenham Hotspur |
| B.Mönchengladbach - Valencia | Atalanta - Dundee United |
| Chelsea - Lille | FC Porto - Sevilla |
| Dundee United - Torino | Lille - FC Twente |
| FC Twente - Sporting | Manchester City - Napoli |
| Fiorentina - FC Porto | RB Leipzig - Fiorentina |
| Napoli - Sassuolo | Sassuolo - B.Mönchengladbach |
| Sevilla - Manchester City | Sporting - Spartak |
| Spartak - VfB Stuttgart | Torino - Chelsea |
| Tottenham Hotspur - Atalanta | Valencia - Villarreal |
| Villarreal - RB Leipzig | VfB Stuttgart - Arsenal |
|
| Round 17 (38) | Round 18 (39) |
| Arsenal - Spartak | Arsenal - Dundee United |
| Aston Villa - VfB Stuttgart | Atalanta - B.Mönchengladbach |
| Atalanta - Sevilla | Chelsea - Manchester City |
| Chelsea - Tottenham Hotspur | FC Twente - Aston Villa |
| FC Twente - B.Mönchengladbach | Fiorentina - Sevilla |
| Lille - Dundee United | Lille - FC Porto |
| Napoli - Fiorentina | Napoli - RB Leipzig |
| RB Leipzig - FC Porto | Sassuolo - VfB Stuttgart |
| Sassuolo - Villarreal | Spartak - Villarreal |
| Sporting - Valencia | Sporting - Torino |
| Torino - Manchester City | Tottenham Hotspur - Valencia |
|
| Round 19 (40) | Round 20 (41) |
| Aston Villa - Atalanta | Arsenal - Manchester City |
| B.Mönchengladbach - Fiorentina | Atalanta - Torino |
| Dundee United - FC Twente | Chelsea - Sevilla |
| FC Porto - Napoli | FC Twente - FC Porto |
| Manchester City - Lille | Fiorentina - Dundee United |
| RB Leipzig - Arsenal | Lille - Aston Villa |
| Sevilla - Spartak | Napoli - VfB Stuttgart |
| Torino - Sassuolo | Sassuolo - Valencia |
| Valencia - Chelsea | Spartak - B.Mönchengladbach |
| VfB Stuttgart - Tottenham Hotspur | Sporting - RB Leipzig |
| Villarreal - Sporting | Tottenham Hotspur - Villarreal |
|
| Round 21 (42) |
| Aston Villa - Sassuolo |
| B.Mönchengladbach - Tottenham Hotspur |
| Dundee United - Spartak |
| FC Porto - Sporting |
| Manchester City - FC Twente |
| RB Leipzig - Atalanta |
| Sevilla - Napoli |
| Torino - Lille |
| Valencia - Arsenal |
| VfB Stuttgart - Chelsea |
| Villarreal - Fiorentina |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Arsenal - Valencia, Atalanta - RB Leipzig etc. |