| Round 1 (22) | Round 2 (23) |
| Anderlecht - Torino | AEK - FC Augsburg |
| Benfica - Athletic Bilbao | Aberdeen - Udinese |
| Celtic - Dundee United | Athletic Bilbao - Grêmio |
| Everton - Aberdeen | Atlético Madrid - Anderlecht |
| FC Augsburg - Roma | Corinthians - Everton |
| FC Basel - Parma | Dundee United - Vélez Sársfield |
| Grêmio - Atlético Madrid | Parma - Celtic |
| Lille - Sassuolo | Roma - Lille |
| Real Sociedad - AEK | Sassuolo - FC Basel |
| Udinese - Corinthians | Torino - Benfica |
| Vélez Sársfield - Zenit | Zenit - Real Sociedad |
|
| Round 3 (24) | Round 4 (25) |
| Anderlecht - Parma | AEK - Celtic |
| Benfica - Corinthians | Aberdeen - Grêmio |
| Celtic - Sassuolo | Athletic Bilbao - Udinese |
| Everton - Atlético Madrid | Atlético Madrid - Benfica |
| FC Augsburg - Aberdeen | Corinthians - Lille |
| FC Basel - Roma | Dundee United - Everton |
| Grêmio - Zenit | Parma - FC Augsburg |
| Lille - AEK | Roma - Vélez Sársfield |
| Real Sociedad - Torino | Sassuolo - Real Sociedad |
| Udinese - Dundee United | Torino - FC Basel |
| Vélez Sársfield - Athletic Bilbao | Zenit - Anderlecht |
|
| Round 5 (26) | Round 6 (27) |
| Anderlecht - Sassuolo | Anderlecht - Celtic |
| Benfica - AEK | Atlético Madrid - Aberdeen |
| Celtic - Roma | Benfica - Everton |
| Everton - Zenit | Dundee United - Athletic Bilbao |
| FC Augsburg - Atlético Madrid | FC Augsburg - Corinthians |
| FC Basel - Aberdeen | FC Basel - Lille |
| Grêmio - Dundee United | Real Sociedad - Vélez Sársfield |
| Lille - Athletic Bilbao | Roma - Parma |
| Real Sociedad - Corinthians | Sassuolo - AEK |
| Udinese - Torino | Udinese - Grêmio |
| Vélez Sársfield - Parma | Zenit - Torino |
|
| Round 7 (28) | Round 8 (29) |
| AEK - Roma | AEK - Grêmio |
| Aberdeen - Zenit | Aberdeen - Corinthians |
| Athletic Bilbao - FC Augsburg | Athletic Bilbao - Torino |
| Celtic - Real Sociedad | Atlético Madrid - Parma |
| Corinthians - Atlético Madrid | Dundee United - Zenit |
| Everton - Udinese | Everton - Celtic |
| Grêmio - Benfica | FC Augsburg - Lille |
| Lille - Anderlecht | Real Sociedad - FC Basel |
| Parma - Sassuolo | Roma - Sassuolo |
| Torino - Dundee United | Udinese - Benfica |
| Vélez Sársfield - FC Basel | Vélez Sársfield - Anderlecht |
|
| Round 9 (30) | Round 10 (31) |
| Anderlecht - Real Sociedad | Aberdeen - Sassuolo |
| Benfica - Dundee United | Athletic Bilbao - AEK |
| Celtic - Vélez Sársfield | Atlético Madrid - Roma |
| Corinthians - Roma | Benfica - Anderlecht |
| FC Basel - FC Augsburg | Corinthians - Celtic |
| Grêmio - Everton | Dundee United - FC Augsburg |
| Lille - Udinese | Everton - FC Basel |
| Parma - AEK | Grêmio - Real Sociedad |
| Sassuolo - Atlético Madrid | Torino - Parma |
| Torino - Aberdeen | Udinese - Vélez Sársfield |
| Zenit - Athletic Bilbao | Zenit - Lille |
|
| Round 11 (32) | Round 12 (33) |
| AEK - Aberdeen | AEK - Torino |
| Anderlecht - Grêmio | Anderlecht - Udinese |
| Celtic - Benfica | Celtic - Grêmio |
| FC Augsburg - Everton | FC Augsburg - Zenit |
| FC Basel - Athletic Bilbao | FC Basel - Corinthians |
| Lille - Dundee United | Lille - Atlético Madrid |
| Parma - Zenit | Parma - Dundee United |
| Real Sociedad - Atlético Madrid | Real Sociedad - Benfica |
| Roma - Udinese | Roma - Everton |
| Sassuolo - Torino | Sassuolo - Athletic Bilbao |
| Vélez Sársfield - Corinthians | Vélez Sársfield - Aberdeen |
|
| Round 13 (34) | Round 14 (35) |
| Aberdeen - Anderlecht | AEK - Dundee United |
| Athletic Bilbao - Parma | Anderlecht - Athletic Bilbao |
| Atlético Madrid - Vélez Sársfield | Celtic - Atlético Madrid |
| Benfica - FC Basel | FC Augsburg - Udinese |
| Corinthians - AEK | FC Basel - Zenit |
| Dundee United - Sassuolo | Lille - Benfica |
| Everton - Real Sociedad | Parma - Everton |
| Grêmio - FC Augsburg | Real Sociedad - Aberdeen |
| Torino - Lille | Roma - Torino |
| Udinese - Celtic | Sassuolo - Corinthians |
| Zenit - Roma | Vélez Sársfield - Grêmio |
|
| Round 15 (36) | Round 16 (37) |
| Aberdeen - Celtic | AEK - Zenit |
| Athletic Bilbao - Roma | Anderlecht - Corinthians |
| Atlético Madrid - AEK | Celtic - Torino |
| Benfica - Vélez Sársfield | FC Augsburg - Benfica |
| Corinthians - Parma | FC Basel - Atlético Madrid |
| Dundee United - FC Basel | Lille - Aberdeen |
| Everton - Anderlecht | Parma - Grêmio |
| Grêmio - Lille | Real Sociedad - Athletic Bilbao |
| Torino - FC Augsburg | Roma - Dundee United |
| Udinese - Real Sociedad | Sassuolo - Udinese |
| Zenit - Sassuolo | Vélez Sársfield - Everton |
|
| Round 17 (38) | Round 18 (39) |
| Anderlecht - Roma | Aberdeen - Roma |
| Benfica - Aberdeen | Anderlecht - FC Augsburg |
| Celtic - Zenit | Atlético Madrid - Zenit |
| Everton - Athletic Bilbao | Benfica - Sassuolo |
| FC Augsburg - Sassuolo | Celtic - Athletic Bilbao |
| FC Basel - AEK | Corinthians - Dundee United |
| Grêmio - Corinthians | Everton - Lille |
| Lille - Parma | Grêmio - Torino |
| Real Sociedad - Dundee United | Real Sociedad - Parma |
| Udinese - Atlético Madrid | Udinese - FC Basel |
| Vélez Sársfield - Torino | Vélez Sársfield - AEK |
|
| Round 19 (40) | Round 20 (41) |
| AEK - Udinese | Aberdeen - Dundee United |
| Athletic Bilbao - Atlético Madrid | Anderlecht - FC Basel |
| Dundee United - Anderlecht | Atlético Madrid - Torino |
| FC Augsburg - Real Sociedad | Benfica - Zenit |
| FC Basel - Grêmio | Celtic - FC Augsburg |
| Lille - Celtic | Corinthians - Athletic Bilbao |
| Parma - Aberdeen | Everton - AEK |
| Roma - Benfica | Grêmio - Sassuolo |
| Sassuolo - Vélez Sársfield | Real Sociedad - Roma |
| Torino - Everton | Udinese - Parma |
| Zenit - Corinthians | Vélez Sársfield - Lille |
|
| Round 21 (42) |
| AEK - Anderlecht |
| Athletic Bilbao - Aberdeen |
| Dundee United - Atlético Madrid |
| FC Augsburg - Vélez Sársfield |
| FC Basel - Celtic |
| Lille - Real Sociedad |
| Parma - Benfica |
| Roma - Grêmio |
| Sassuolo - Everton |
| Torino - Corinthians |
| Zenit - Udinese |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Aberdeen - Athletic Bilbao, Anderlecht - AEK etc. |