| Round 1 (22) | Round 2 (23) |
| Athletic Bilbao - Grasshoppers | Bordeaux - Rubin |
| Carlisle United - Inter | Bursaspor - TSG Hoffenheim |
| Celtic - Rosenborg | Grasshoppers - Celtic |
| Cruz Azul - Sevilla | Hamburger SV - Carlisle United |
| Fiorentina - Bordeaux | Inter - Cruz Azul |
| River Plate - Napoli | Marseille - Viktoria Plzen |
| Rubin - Marseille | Napoli - West Ham United |
| TSG Hoffenheim - Shakhtar | Rosenborg - Fiorentina |
| Udinese - Hamburger SV | Sampdoria - River Plate |
| Viktoria Plzen - Bursaspor | Sevilla - Udinese |
| West Ham United - Sampdoria | Shakhtar - Athletic Bilbao |
|
| Round 3 (24) | Round 4 (25) |
| Athletic Bilbao - Bursaspor | Bordeaux - Carlisle United |
| Carlisle United - Grasshoppers | Bursaspor - Fiorentina |
| Celtic - Shakhtar | Grasshoppers - Viktoria Plzen |
| Cruz Azul - Sampdoria | Hamburger SV - Cruz Azul |
| Fiorentina - Sevilla | Inter - Athletic Bilbao |
| River Plate - Hamburger SV | Marseille - Celtic |
| Rubin - Inter | Napoli - Udinese |
| TSG Hoffenheim - Marseille | Rosenborg - River Plate |
| Udinese - Bordeaux | Sampdoria - TSG Hoffenheim |
| Viktoria Plzen - Napoli | Sevilla - West Ham United |
| West Ham United - Rosenborg | Shakhtar - Rubin |
|
| Round 5 (26) | Round 6 (27) |
| Athletic Bilbao - Napoli | Athletic Bilbao - TSG Hoffenheim |
| Carlisle United - Shakhtar | Bordeaux - Inter |
| Celtic - Bursaspor | Bursaspor - Grasshoppers |
| Cruz Azul - Marseille | Carlisle United - Celtic |
| Fiorentina - Grasshoppers | Cruz Azul - River Plate |
| River Plate - Bordeaux | Hamburger SV - Napoli |
| Rubin - Sampdoria | Rosenborg - Sevilla |
| TSG Hoffenheim - Sevilla | Rubin - Fiorentina |
| Udinese - Rosenborg | Shakhtar - Marseille |
| Viktoria Plzen - Hamburger SV | Viktoria Plzen - Sampdoria |
| West Ham United - Inter | West Ham United - Udinese |
|
| Round 7 (28) | Round 8 (29) |
| Celtic - Rubin | Bursaspor - Shakhtar |
| Fiorentina - Athletic Bilbao | Fiorentina - Carlisle United |
| Grasshoppers - Shakhtar | Hamburger SV - Grasshoppers |
| Inter - Rosenborg | Marseille - Udinese |
| Marseille - Bursaspor | Napoli - Sampdoria |
| Napoli - Bordeaux | River Plate - Celtic |
| River Plate - West Ham United | Rosenborg - Bordeaux |
| Sampdoria - Hamburger SV | Rubin - Athletic Bilbao |
| Sevilla - Viktoria Plzen | Sevilla - Inter |
| TSG Hoffenheim - Carlisle United | Viktoria Plzen - TSG Hoffenheim |
| Udinese - Cruz Azul | West Ham United - Cruz Azul |
|
| Round 9 (30) | Round 10 (31) |
| Athletic Bilbao - Viktoria Plzen | Bordeaux - TSG Hoffenheim |
| Bordeaux - Sevilla | Cruz Azul - Carlisle United |
| Carlisle United - Rubin | Hamburger SV - Bursaspor |
| Celtic - Fiorentina | Inter - Grasshoppers |
| Cruz Azul - Rosenborg | Napoli - Shakhtar |
| Grasshoppers - Marseille | River Plate - Athletic Bilbao |
| Inter - Napoli | Rosenborg - Viktoria Plzen |
| Sampdoria - Bursaspor | Sampdoria - Celtic |
| Shakhtar - Hamburger SV | Sevilla - Marseille |
| TSG Hoffenheim - West Ham United | Udinese - Rubin |
| Udinese - River Plate | West Ham United - Fiorentina |
|
| Round 11 (32) | Round 12 (33) |
| Athletic Bilbao - Sevilla | Athletic Bilbao - Sampdoria |
| Bursaspor - West Ham United | Bursaspor - River Plate |
| Carlisle United - Udinese | Carlisle United - West Ham United |
| Celtic - Cruz Azul | Celtic - Udinese |
| Fiorentina - Sampdoria | Fiorentina - Napoli |
| Grasshoppers - Bordeaux | Grasshoppers - Rosenborg |
| Marseille - Napoli | Marseille - Inter |
| Rubin - Hamburger SV | Rubin - Cruz Azul |
| Shakhtar - Inter | Shakhtar - Sevilla |
| TSG Hoffenheim - Rosenborg | TSG Hoffenheim - Hamburger SV |
| Viktoria Plzen - River Plate | Viktoria Plzen - Bordeaux |
|
| Round 13 (34) | Round 14 (35) |
| Bordeaux - Bursaspor | Athletic Bilbao - Bordeaux |
| Cruz Azul - Athletic Bilbao | Bursaspor - Inter |
| Hamburger SV - Fiorentina | Carlisle United - Sevilla |
| Inter - TSG Hoffenheim | Celtic - Hamburger SV |
| Napoli - Carlisle United | Fiorentina - Udinese |
| River Plate - Rubin | Grasshoppers - River Plate |
| Rosenborg - Shakhtar | Marseille - Rosenborg |
| Sampdoria - Marseille | Rubin - Napoli |
| Sevilla - Grasshoppers | Shakhtar - Sampdoria |
| Udinese - Viktoria Plzen | TSG Hoffenheim - Cruz Azul |
| West Ham United - Celtic | Viktoria Plzen - West Ham United |
|
| Round 15 (36) | Round 16 (37) |
| Bordeaux - Shakhtar | Athletic Bilbao - Hamburger SV |
| Cruz Azul - Fiorentina | Bursaspor - Rosenborg |
| Hamburger SV - Marseille | Carlisle United - Sampdoria |
| Inter - Viktoria Plzen | Celtic - Inter |
| Napoli - Celtic | Fiorentina - River Plate |
| River Plate - Carlisle United | Grasshoppers - Udinese |
| Rosenborg - Athletic Bilbao | Marseille - Bordeaux |
| Sampdoria - Grasshoppers | Rubin - Sevilla |
| Sevilla - Bursaspor | Shakhtar - West Ham United |
| Udinese - TSG Hoffenheim | TSG Hoffenheim - Napoli |
| West Ham United - Rubin | Viktoria Plzen - Cruz Azul |
|
| Round 17 (38) | Round 18 (39) |
| Athletic Bilbao - Marseille | Carlisle United - Viktoria Plzen |
| Carlisle United - Bursaspor | Celtic - Sevilla |
| Celtic - Bordeaux | Cruz Azul - Shakhtar |
| Cruz Azul - Napoli | Fiorentina - Marseille |
| Fiorentina - Inter | Hamburger SV - Bordeaux |
| River Plate - Sevilla | Napoli - Bursaspor |
| Rubin - Rosenborg | River Plate - TSG Hoffenheim |
| TSG Hoffenheim - Grasshoppers | Rubin - Grasshoppers |
| Udinese - Sampdoria | Sampdoria - Rosenborg |
| Viktoria Plzen - Shakhtar | Udinese - Inter |
| West Ham United - Hamburger SV | West Ham United - Athletic Bilbao |
|
| Round 19 (40) | Round 20 (41) |
| Athletic Bilbao - Udinese | Carlisle United - Athletic Bilbao |
| Bordeaux - Sampdoria | Celtic - Viktoria Plzen |
| Bursaspor - Cruz Azul | Cruz Azul - Bordeaux |
| Grasshoppers - Napoli | Fiorentina - TSG Hoffenheim |
| Inter - River Plate | Hamburger SV - Inter |
| Marseille - West Ham United | Napoli - Rosenborg |
| Rosenborg - Carlisle United | River Plate - Marseille |
| Sevilla - Hamburger SV | Rubin - Bursaspor |
| Shakhtar - Fiorentina | Sampdoria - Sevilla |
| TSG Hoffenheim - Celtic | Udinese - Shakhtar |
| Viktoria Plzen - Rubin | West Ham United - Grasshoppers |
|
| Round 21 (42) |
| Athletic Bilbao - Celtic |
| Bordeaux - West Ham United |
| Bursaspor - Udinese |
| Grasshoppers - Cruz Azul |
| Inter - Sampdoria |
| Marseille - Carlisle United |
| Rosenborg - Hamburger SV |
| Sevilla - Napoli |
| Shakhtar - River Plate |
| TSG Hoffenheim - Rubin |
| Viktoria Plzen - Fiorentina |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Carlisle United - Marseille, Celtic - Athletic Bilbao etc. |