| Round 1 (22) | Round 2 (23) |
| Belenenses - Hajduk Split | Aston Villa - Palmeiras |
| Besiktas - CSKA | Boulogne - Belenenses |
| Boca Juniors - FC Utrecht | CSKA - VfL Wolfsburg |
| FC Schalke 04 - VfB Stuttgart | Club Brugge - Real Betis |
| Genoa - Girona | FC Utrecht - Juventus |
| Juventus - Olympiakos | Girona - FC Schalke 04 |
| Leicester City - SV Werder Bremen | Guingamp - Besiktas |
| Palmeiras - Guingamp | Hajduk Split - Leicester City |
| Rangers - Club Brugge | Olympiakos - Boca Juniors |
| Real Betis - Boulogne | SV Werder Bremen - Genoa |
| VfL Wolfsburg - Aston Villa | VfB Stuttgart - Rangers |
|
| Round 3 (24) | Round 4 (25) |
| Belenenses - Club Brugge | Aston Villa - Juventus |
| Besiktas - Hajduk Split | Boulogne - FC Schalke 04 |
| Boca Juniors - Guingamp | CSKA - Belenenses |
| FC Schalke 04 - CSKA | Club Brugge - Genoa |
| Genoa - Aston Villa | FC Utrecht - Palmeiras |
| Juventus - SV Werder Bremen | Girona - Besiktas |
| Leicester City - Boulogne | Guingamp - VfL Wolfsburg |
| Palmeiras - Girona | Hajduk Split - Rangers |
| Rangers - FC Utrecht | Olympiakos - Real Betis |
| Real Betis - VfB Stuttgart | SV Werder Bremen - Boca Juniors |
| VfL Wolfsburg - Olympiakos | VfB Stuttgart - Leicester City |
|
| Round 5 (26) | Round 6 (27) |
| Belenenses - FC Utrecht | Belenenses - Real Betis |
| Besiktas - Boulogne | Besiktas - Leicester City |
| Boca Juniors - Girona | Boulogne - VfB Stuttgart |
| FC Schalke 04 - Olympiakos | Club Brugge - Hajduk Split |
| Genoa - Hajduk Split | FC Schalke 04 - Genoa |
| Juventus - CSKA | Girona - CSKA |
| Leicester City - Club Brugge | Guingamp - FC Utrecht |
| Palmeiras - SV Werder Bremen | Juventus - Palmeiras |
| Rangers - Guingamp | Rangers - Olympiakos |
| Real Betis - Aston Villa | SV Werder Bremen - Aston Villa |
| VfL Wolfsburg - VfB Stuttgart | VfL Wolfsburg - Boca Juniors |
|
| Round 7 (28) | Round 8 (29) |
| Aston Villa - Rangers | Aston Villa - CSKA |
| Boca Juniors - Juventus | Boca Juniors - Leicester City |
| CSKA - SV Werder Bremen | Club Brugge - Boulogne |
| FC Utrecht - Girona | FC Schalke 04 - Belenenses |
| Genoa - Belenenses | FC Utrecht - Olympiakos |
| Hajduk Split - Boulogne | Genoa - Besiktas |
| Leicester City - FC Schalke 04 | Guingamp - Hajduk Split |
| Olympiakos - Guingamp | Juventus - VfL Wolfsburg |
| Palmeiras - VfL Wolfsburg | Rangers - Real Betis |
| Real Betis - Besiktas | SV Werder Bremen - Girona |
| VfB Stuttgart - Club Brugge | VfB Stuttgart - Palmeiras |
|
| Round 9 (30) | Round 10 (31) |
| Belenenses - Rangers | Aston Villa - VfB Stuttgart |
| Besiktas - FC Schalke 04 | Boca Juniors - Belenenses |
| Boulogne - Guingamp | CSKA - Hajduk Split |
| CSKA - FC Utrecht | FC Utrecht - Boulogne |
| Girona - Aston Villa | Girona - Real Betis |
| Hajduk Split - VfB Stuttgart | Guingamp - Club Brugge |
| Leicester City - Genoa | Juventus - Genoa |
| Olympiakos - Club Brugge | Olympiakos - Leicester City |
| Palmeiras - Boca Juniors | Palmeiras - FC Schalke 04 |
| Real Betis - Juventus | SV Werder Bremen - Rangers |
| VfL Wolfsburg - SV Werder Bremen | VfL Wolfsburg - Besiktas |
|
| Round 11 (32) | Round 12 (33) |
| Belenenses - Aston Villa | Belenenses - Olympiakos |
| Besiktas - Palmeiras | Besiktas - Juventus |
| Boulogne - CSKA | Boulogne - Aston Villa |
| Club Brugge - Juventus | Club Brugge - Boca Juniors |
| FC Schalke 04 - Guingamp | FC Schalke 04 - VfL Wolfsburg |
| Genoa - Olympiakos | Genoa - FC Utrecht |
| Hajduk Split - Girona | Hajduk Split - SV Werder Bremen |
| Leicester City - VfL Wolfsburg | Leicester City - Palmeiras |
| Rangers - Boca Juniors | Rangers - Girona |
| Real Betis - SV Werder Bremen | Real Betis - Guingamp |
| VfB Stuttgart - FC Utrecht | VfB Stuttgart - CSKA |
|
| Round 13 (34) | Round 14 (35) |
| Aston Villa - Hajduk Split | Belenenses - Girona |
| Boca Juniors - FC Schalke 04 | Besiktas - Aston Villa |
| CSKA - Real Betis | Boulogne - Olympiakos |
| FC Utrecht - Besiktas | Club Brugge - CSKA |
| Girona - Club Brugge | FC Schalke 04 - FC Utrecht |
| Guingamp - Genoa | Genoa - Palmeiras |
| Juventus - Leicester City | Hajduk Split - Boca Juniors |
| Olympiakos - VfB Stuttgart | Leicester City - Guingamp |
| Palmeiras - Rangers | Rangers - Juventus |
| SV Werder Bremen - Boulogne | Real Betis - VfL Wolfsburg |
| VfL Wolfsburg - Belenenses | VfB Stuttgart - SV Werder Bremen |
|
| Round 15 (36) | Round 16 (37) |
| Aston Villa - Club Brugge | Belenenses - Guingamp |
| Boca Juniors - Besiktas | Besiktas - Olympiakos |
| CSKA - Rangers | Boulogne - Juventus |
| FC Utrecht - Leicester City | Club Brugge - SV Werder Bremen |
| Girona - Boulogne | FC Schalke 04 - Aston Villa |
| Guingamp - VfB Stuttgart | Genoa - Boca Juniors |
| Juventus - FC Schalke 04 | Hajduk Split - Palmeiras |
| Olympiakos - Hajduk Split | Leicester City - CSKA |
| Palmeiras - Real Betis | Rangers - VfL Wolfsburg |
| SV Werder Bremen - Belenenses | Real Betis - FC Utrecht |
| VfL Wolfsburg - Genoa | VfB Stuttgart - Girona |
|
| Round 17 (38) | Round 18 (39) |
| Belenenses - VfB Stuttgart | Besiktas - Rangers |
| Besiktas - Club Brugge | Boca Juniors - Real Betis |
| Boca Juniors - Aston Villa | FC Schalke 04 - Hajduk Split |
| FC Schalke 04 - SV Werder Bremen | FC Utrecht - Club Brugge |
| Genoa - CSKA | Genoa - VfB Stuttgart |
| Juventus - Guingamp | Guingamp - Girona |
| Leicester City - Girona | Juventus - Belenenses |
| Palmeiras - Olympiakos | Leicester City - Aston Villa |
| Rangers - Boulogne | Olympiakos - SV Werder Bremen |
| Real Betis - Hajduk Split | Palmeiras - CSKA |
| VfL Wolfsburg - FC Utrecht | VfL Wolfsburg - Boulogne |
|
| Round 19 (40) | Round 20 (41) |
| Aston Villa - Guingamp | Besiktas - Belenenses |
| Belenenses - Palmeiras | Boca Juniors - VfB Stuttgart |
| Boulogne - Genoa | FC Schalke 04 - Club Brugge |
| CSKA - Boca Juniors | FC Utrecht - SV Werder Bremen |
| Club Brugge - VfL Wolfsburg | Genoa - Real Betis |
| Girona - Olympiakos | Guingamp - CSKA |
| Hajduk Split - FC Utrecht | Juventus - Hajduk Split |
| Rangers - FC Schalke 04 | Leicester City - Rangers |
| Real Betis - Leicester City | Olympiakos - Aston Villa |
| SV Werder Bremen - Besiktas | Palmeiras - Boulogne |
| VfB Stuttgart - Juventus | VfL Wolfsburg - Girona |
|
| Round 21 (42) |
| Aston Villa - FC Utrecht |
| Belenenses - Leicester City |
| Boulogne - Boca Juniors |
| CSKA - Olympiakos |
| Club Brugge - Palmeiras |
| Girona - Juventus |
| Hajduk Split - VfL Wolfsburg |
| Rangers - Genoa |
| Real Betis - FC Schalke 04 |
| SV Werder Bremen - Guingamp |
| VfB Stuttgart - Besiktas |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Besiktas - VfB Stuttgart, Boca Juniors - Boulogne etc. |