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| Round 1 (22) Bayer Leverkusen - Leicester City Borussia Dortmund - Espanyol Chelsea - West Ham United Club Brugge - Atlético-MG Dinamo Zagreb - Valencia Fenerbahçe - Blackburn Rovers Feyenoord - Everton Lyon - Hamburger SV Santos - Sampdoria Sevilla - Monaco Wolves - Real Sociedad | Round 2 (23) Atlético-MG - Chelsea Blackburn Rovers - Feyenoord Espanyol - Santos Everton - Wolves Hamburger SV - Bayer Leverkusen Leicester City - Dinamo Zagreb Monaco - Borussia Dortmund Real Sociedad - Fenerbahçe Sampdoria - Lyon Valencia - Sevilla West Ham United - Club Brugge |
| Round 3 (24) Bayer Leverkusen - West Ham United Borussia Dortmund - Valencia Chelsea - Blackburn Rovers Club Brugge - Espanyol Dinamo Zagreb - Hamburger SV Fenerbahçe - Sampdoria Feyenoord - Monaco Lyon - Everton Santos - Real Sociedad Sevilla - Leicester City Wolves - Atlético-MG | Round 4 (25) Atlético-MG - Dinamo Zagreb Blackburn Rovers - Wolves Espanyol - Chelsea Everton - Sevilla Hamburger SV - Borussia Dortmund Leicester City - Santos Monaco - Bayer Leverkusen Real Sociedad - Club Brugge Sampdoria - Feyenoord Valencia - Lyon West Ham United - Fenerbahçe |
| Round 5 (26) Bayer Leverkusen - Blackburn Rovers Borussia Dortmund - Leicester City Chelsea - Sampdoria Club Brugge - Everton Dinamo Zagreb - Real Sociedad Fenerbahçe - Espanyol Feyenoord - Valencia Lyon - Atlético-MG Santos - Monaco Sevilla - West Ham United Wolves - Hamburger SV | Round 6 (27) Bayer Leverkusen - Atlético-MG Blackburn Rovers - West Ham United Club Brugge - Fenerbahçe Espanyol - Real Sociedad Feyenoord - Borussia Dortmund Leicester City - Monaco Lyon - Santos Sampdoria - Everton Sevilla - Dinamo Zagreb Valencia - Hamburger SV Wolves - Chelsea |
| Round 7 (28) Atlético-MG - Blackburn Rovers Borussia Dortmund - Lyon Chelsea - Club Brugge Dinamo Zagreb - Feyenoord Everton - Espanyol Fenerbahçe - Wolves Hamburger SV - Leicester City Monaco - Valencia Real Sociedad - Bayer Leverkusen Santos - Sevilla West Ham United - Sampdoria | Round 8 (29) Bayer Leverkusen - Dinamo Zagreb Blackburn Rovers - Monaco Chelsea - Borussia Dortmund Club Brugge - Wolves Espanyol - Sampdoria Hamburger SV - Fenerbahçe Leicester City - Valencia Lyon - Sevilla Real Sociedad - Everton Santos - Feyenoord West Ham United - Atlético-MG |
| Round 9 (30) Atlético-MG - Leicester City Borussia Dortmund - Santos Dinamo Zagreb - Club Brugge Everton - West Ham United Fenerbahçe - Chelsea Feyenoord - Lyon Monaco - Hamburger SV Sampdoria - Real Sociedad Sevilla - Bayer Leverkusen Valencia - Blackburn Rovers Wolves - Espanyol | Round 10 (31) Atlético-MG - Borussia Dortmund Blackburn Rovers - Leicester City Chelsea - Sevilla Club Brugge - Santos Espanyol - Bayer Leverkusen Everton - Monaco Fenerbahçe - Lyon Real Sociedad - Hamburger SV Sampdoria - Dinamo Zagreb West Ham United - Valencia Wolves - Feyenoord |
| Round 11 (32) Bayer Leverkusen - Chelsea Borussia Dortmund - Wolves Dinamo Zagreb - Espanyol Feyenoord - Fenerbahçe Hamburger SV - West Ham United Leicester City - Club Brugge Lyon - Blackburn Rovers Monaco - Sampdoria Santos - Atlético-MG Sevilla - Real Sociedad Valencia - Everton | Round 12 (33) Bayer Leverkusen - Sampdoria Borussia Dortmund - Fenerbahçe Dinamo Zagreb - Blackburn Rovers Feyenoord - Club Brugge Hamburger SV - Everton Leicester City - Chelsea Lyon - Wolves Monaco - Espanyol Santos - West Ham United Sevilla - Atlético-MG Valencia - Real Sociedad |
| Round 13 (34) Atlético-MG - Hamburger SV Blackburn Rovers - Santos Chelsea - Lyon Club Brugge - Borussia Dortmund Espanyol - Valencia Everton - Dinamo Zagreb Fenerbahçe - Bayer Leverkusen Real Sociedad - Monaco Sampdoria - Leicester City West Ham United - Feyenoord Wolves - Sevilla | Round 14 (35) Bayer Leverkusen - Club Brugge Borussia Dortmund - Blackburn Rovers Dinamo Zagreb - Wolves Feyenoord - Real Sociedad Hamburger SV - Espanyol Leicester City - Everton Lyon - West Ham United Monaco - Chelsea Santos - Fenerbahçe Sevilla - Sampdoria Valencia - Atlético-MG |
| Round 15 (36) Atlético-MG - Monaco Blackburn Rovers - Hamburger SV Chelsea - Feyenoord Club Brugge - Lyon Espanyol - Sevilla Everton - Bayer Leverkusen Fenerbahçe - Dinamo Zagreb Real Sociedad - Leicester City Sampdoria - Valencia West Ham United - Borussia Dortmund Wolves - Santos | Round 16 (37) Bayer Leverkusen - Wolves Borussia Dortmund - Everton Dinamo Zagreb - West Ham United Feyenoord - Atlético-MG Hamburger SV - Sampdoria Leicester City - Espanyol Lyon - Real Sociedad Monaco - Fenerbahçe Santos - Chelsea Sevilla - Blackburn Rovers Valencia - Club Brugge |
| Round 17 (38) Bayer Leverkusen - Valencia Borussia Dortmund - Sampdoria Chelsea - Real Sociedad Club Brugge - Blackburn Rovers Dinamo Zagreb - Monaco Fenerbahçe - Atlético-MG Feyenoord - Leicester City Lyon - Espanyol Santos - Everton Sevilla - Hamburger SV Wolves - West Ham United | Round 18 (39) Atlético-MG - Espanyol Blackburn Rovers - Sampdoria Borussia Dortmund - Real Sociedad Chelsea - Dinamo Zagreb Club Brugge - Sevilla Fenerbahçe - Everton Feyenoord - Bayer Leverkusen Lyon - Monaco Santos - Hamburger SV West Ham United - Leicester City Wolves - Valencia |
| Round 19 (40) Bayer Leverkusen - Lyon Dinamo Zagreb - Borussia Dortmund Espanyol - Feyenoord Everton - Chelsea Hamburger SV - Club Brugge Leicester City - Wolves Monaco - West Ham United Real Sociedad - Blackburn Rovers Sampdoria - Atlético-MG Sevilla - Fenerbahçe Valencia - Santos | Round 20 (41) Atlético-MG - Real Sociedad Blackburn Rovers - Everton Borussia Dortmund - Bayer Leverkusen Chelsea - Hamburger SV Club Brugge - Monaco Fenerbahçe - Valencia Feyenoord - Sevilla Lyon - Leicester City Santos - Dinamo Zagreb West Ham United - Espanyol Wolves - Sampdoria |
| Round 21 (42) Bayer Leverkusen - Santos Dinamo Zagreb - Lyon Espanyol - Blackburn Rovers Everton - Atlético-MG Hamburger SV - Feyenoord Leicester City - Fenerbahçe Monaco - Wolves Real Sociedad - West Ham United Sampdoria - Club Brugge Sevilla - Borussia Dortmund Valencia - Chelsea | |
| League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above, i.e. round 42 is Atlético-MG - Everton, Blackburn Rovers - Espanyol etc. | |