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| Round 1 (22) 1.FC Union Berlin - FC Porto FC Schalke 04 - Fort. Düsseldorf Grêmio - Zaragoza Hansa Rostock - Leeds United Hertha BSC Berlin - Vélez Sársfield Lokomotiv - Tottenham Hotspur Parma - Mallorca RB Leipzig - CSKA Rayo Vallecano - Hearts Real Betis - Atalanta Udinese - 1.FC Köln | Round 2 (23) 1.FC Köln - 1.FC Union Berlin Atalanta - Grêmio CSKA - Hertha BSC Berlin FC Porto - FC Schalke 04 Fort. Düsseldorf - RB Leipzig Hearts - Udinese Leeds United - Real Betis Mallorca - Lokomotiv Tottenham Hotspur - Parma Vélez Sársfield - Rayo Vallecano Zaragoza - Hansa Rostock |
| Round 3 (24) 1.FC Union Berlin - Hearts FC Schalke 04 - Zaragoza Grêmio - Mallorca Hansa Rostock - Fort. Düsseldorf Hertha BSC Berlin - Tottenham Hotspur Lokomotiv - Leeds United Parma - FC Porto RB Leipzig - Atalanta Rayo Vallecano - CSKA Real Betis - 1.FC Köln Udinese - Vélez Sársfield | Round 4 (25) 1.FC Köln - Hertha BSC Berlin Atalanta - Udinese CSKA - 1.FC Union Berlin FC Porto - Lokomotiv Fort. Düsseldorf - Real Betis Hearts - RB Leipzig Leeds United - Grêmio Mallorca - Rayo Vallecano Tottenham Hotspur - Hansa Rostock Vélez Sársfield - FC Schalke 04 Zaragoza - Parma |
| Round 5 (26) 1.FC Union Berlin - Vélez Sársfield FC Schalke 04 - 1.FC Köln Grêmio - CSKA Hansa Rostock - FC Porto Hertha BSC Berlin - Leeds United Lokomotiv - Fort. Düsseldorf Parma - Atalanta RB Leipzig - Mallorca Rayo Vallecano - Zaragoza Real Betis - Hearts Udinese - Tottenham Hotspur | Round 6 (27) FC Porto - Zaragoza Fort. Düsseldorf - Atalanta Grêmio - Lokomotiv Hearts - CSKA Hertha BSC Berlin - Mallorca Leeds United - Tottenham Hotspur Parma - Hansa Rostock RB Leipzig - FC Schalke 04 Real Betis - 1.FC Union Berlin Udinese - Rayo Vallecano Vélez Sársfield - 1.FC Köln |
| Round 7 (28) 1.FC Köln - Hearts 1.FC Union Berlin - RB Leipzig Atalanta - FC Porto CSKA - Vélez Sársfield FC Schalke 04 - Udinese Hansa Rostock - Grêmio Lokomotiv - Parma Mallorca - Leeds United Rayo Vallecano - Real Betis Tottenham Hotspur - Fort. Düsseldorf Zaragoza - Hertha BSC Berlin | Round 8 (29) CSKA - Hansa Rostock FC Porto - Fort. Düsseldorf FC Schalke 04 - Real Betis Hertha BSC Berlin - Rayo Vallecano Leeds United - 1.FC Köln Lokomotiv - 1.FC Union Berlin Parma - Grêmio RB Leipzig - Udinese Tottenham Hotspur - Mallorca Vélez Sársfield - Hearts Zaragoza - Atalanta |
| Round 9 (30) 1.FC Köln - CSKA 1.FC Union Berlin - FC Schalke 04 Atalanta - Tottenham Hotspur Fort. Düsseldorf - Zaragoza Grêmio - FC Porto Hansa Rostock - Lokomotiv Hearts - Leeds United Mallorca - Vélez Sársfield Rayo Vallecano - Parma Real Betis - RB Leipzig Udinese - Hertha BSC Berlin | Round 10 (31) Atalanta - 1.FC Köln FC Porto - Hertha BSC Berlin Fort. Düsseldorf - Rayo Vallecano Grêmio - Real Betis Hansa Rostock - RB Leipzig Leeds United - Vélez Sársfield Lokomotiv - Udinese Mallorca - 1.FC Union Berlin Parma - FC Schalke 04 Tottenham Hotspur - Hearts Zaragoza - CSKA |
| Round 11 (32) 1.FC Köln - Fort. Düsseldorf 1.FC Union Berlin - Grêmio CSKA - Tottenham Hotspur FC Schalke 04 - Mallorca Hearts - Atalanta Hertha BSC Berlin - Lokomotiv RB Leipzig - Leeds United Rayo Vallecano - FC Porto Real Betis - Hansa Rostock Udinese - Zaragoza Vélez Sársfield - Parma | Round 12 (33) 1.FC Köln - FC Porto 1.FC Union Berlin - Hansa Rostock CSKA - Atalanta FC Schalke 04 - Tottenham Hotspur Hearts - Zaragoza Hertha BSC Berlin - Fort. Düsseldorf RB Leipzig - Grêmio Rayo Vallecano - Leeds United Real Betis - Parma Udinese - Mallorca Vélez Sársfield - Lokomotiv |
| Round 13 (34) Atalanta - Rayo Vallecano FC Porto - Hearts Fort. Düsseldorf - Vélez Sársfield Grêmio - Udinese Hansa Rostock - Hertha BSC Berlin Leeds United - FC Schalke 04 Lokomotiv - RB Leipzig Mallorca - CSKA Parma - 1.FC Union Berlin Tottenham Hotspur - Real Betis Zaragoza - 1.FC Köln | Round 14 (35) 1.FC Köln - Lokomotiv 1.FC Union Berlin - Leeds United CSKA - FC Porto FC Schalke 04 - Hansa Rostock Hearts - Mallorca Hertha BSC Berlin - Parma RB Leipzig - Tottenham Hotspur Rayo Vallecano - Grêmio Real Betis - Zaragoza Udinese - Fort. Düsseldorf Vélez Sársfield - Atalanta |
| Round 15 (36) Atalanta - Hertha BSC Berlin FC Porto - Udinese Fort. Düsseldorf - Hearts Grêmio - FC Schalke 04 Hansa Rostock - Rayo Vallecano Leeds United - CSKA Lokomotiv - Real Betis Mallorca - 1.FC Köln Parma - RB Leipzig Tottenham Hotspur - 1.FC Union Berlin Zaragoza - Vélez Sársfield | Round 16 (37) 1.FC Köln - Hansa Rostock 1.FC Union Berlin - Atalanta CSKA - Fort. Düsseldorf FC Schalke 04 - Lokomotiv Hearts - Parma Hertha BSC Berlin - Grêmio RB Leipzig - Zaragoza Rayo Vallecano - Tottenham Hotspur Real Betis - Mallorca Udinese - Leeds United Vélez Sársfield - FC Porto |
| Round 17 (38) 1.FC Union Berlin - Fort. Düsseldorf FC Schalke 04 - Atalanta Grêmio - Tottenham Hotspur Hansa Rostock - Mallorca Hertha BSC Berlin - Hearts Lokomotiv - Zaragoza Parma - Leeds United RB Leipzig - FC Porto Rayo Vallecano - 1.FC Köln Real Betis - Vélez Sársfield Udinese - CSKA | Round 18 (39) 1.FC Union Berlin - Zaragoza FC Schalke 04 - CSKA Grêmio - Hearts Hansa Rostock - Atalanta Leeds United - Fort. Düsseldorf Lokomotiv - Rayo Vallecano Mallorca - FC Porto Parma - Udinese RB Leipzig - 1.FC Köln Real Betis - Hertha BSC Berlin Tottenham Hotspur - Vélez Sársfield |
| Round 19 (40) 1.FC Köln - Tottenham Hotspur Atalanta - Lokomotiv CSKA - Parma FC Porto - Real Betis Fort. Düsseldorf - Mallorca Hearts - FC Schalke 04 Hertha BSC Berlin - RB Leipzig Rayo Vallecano - 1.FC Union Berlin Udinese - Hansa Rostock Vélez Sársfield - Grêmio Zaragoza - Leeds United | Round 20 (41) 1.FC Union Berlin - Hertha BSC Berlin FC Schalke 04 - Rayo Vallecano Grêmio - Fort. Düsseldorf Hansa Rostock - Hearts Leeds United - Atalanta Lokomotiv - CSKA Mallorca - Zaragoza Parma - 1.FC Köln RB Leipzig - Vélez Sársfield Real Betis - Udinese Tottenham Hotspur - FC Porto |
| Round 21 (42) 1.FC Köln - Grêmio Atalanta - Mallorca CSKA - Real Betis FC Porto - Leeds United Fort. Düsseldorf - Parma Hearts - Lokomotiv Hertha BSC Berlin - FC Schalke 04 Rayo Vallecano - RB Leipzig Udinese - 1.FC Union Berlin Vélez Sársfield - Hansa Rostock Zaragoza - Tottenham Hotspur | |
| League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above, i.e. round 42 is 1.FC Union Berlin - Udinese, FC Schalke 04 - Hertha BSC Berlin etc. | |