| Round 5 | | Barnsley | 0 |
| | Half-time: | 0-0 | | Referee: | Penicka 5½ | | Attendance: | 68,130 | | Possession: | 53%-47% | | Total shots: | 10-17 | | MoM: | Clichy |
| | 10 Giggs | | (4-3-3): James 6½, Carragher 7 (58 Sinama-Pongolle 6), Jankulovski 7½, Del Piero 7 (58 King 7½), Terry 6, Juan 6½, Gago 6½, Giggs 6½, Ibrahimovic 7, Martins 6, Raúl 7½ | | Swansea City | 1 | 62 Maxwell | | 78 Maxwell | | (4-4-2): Mandanda 7, Miguel 6½, Clichy 8, Kompany 6½, Zapata 6½, Pepe 6, Schweinsteiger 6½, Maxwell 6½, Totti 7, Ballack 7, Benzema 5½ | | Birmingham City | 1 | 30og Marcelo Mattos | | Half-time: | 1-1 | | Referee: | Marriner 6 | | Attendance: | 45,771 | | Possession: | 51%-49% | | Total shots: | 15-9 | | MoM: | Giuly | | TV: | highlights |
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| | (4-4-2): Boruc 7, Gurenko 7, Capdevila 7½, Giuly 8, Touré 7½, Cuéllar 7½, Van Bommel 7, Bresciano 7½, Crespo 7, Ferguson 7, Diogo 6 | | Nottingham Forest | 1 | 21 Woodgate |
| | (4-3-3): Rui Patrício 7½, Ángel 7½, Woodgate 6½, Fellaini 7½, Marcelo Mattos 7, Davies 6, Izmailov 6, Fernandinho 6, Drogba 7, Juanfran 5½, Albín 6 | | Burnley | 2 | 21 Noble, 37 Fletcher | | Half-time: | 2-0 | | Referee: | Dean 6½ | | Attendance: | 50,484 | | Possession: | 57%-43% | | Total shots: | 12-11 | | MoM: | Fletcher | | TV: | highlights |
| | 41 Noble | | (4-3-3): Gordon 6, Young 7½, Neville 7½, Fletcher 8, Hughes 7, Jagielka 6½, Bentley 6 (76 Davis 6), Noble 6½, Cole 7½, Ireland 6, Downing 7 | | Bournemouth | 2 | 61 Ibisevic, 83 Vucinic |
| | (4-1-3-2): Palop 6½, Eboué 6½, Schäfer 7 (66 Pepe 7½), Frings 7 (71 Halil 7), Ivanovic 7, Tasci 6, Krasic 6½, Özil 7, Ibisevic 7½, Afellay 5½, Vucinic 6½ | | Chelsea | 2 | 27 Xavi, 45 Klose | | Half-time: | 2-1 | | Referee: | Halsey 7½ | | Attendance: | 47,087 | | Possession: | 48%-52% | | Total shots: | 16-16 | | MoM: | Riise |
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| | (4-4-2): Foster 6½, Gallas 7, Riise 8, Xavi 7½, Piqué 7, Bruno Alves 7, Navas 6½, D'Agostino 6½, Milito 7½, Klose 6½, Robinho 7 | | Manchester United | 2 | 19 Rodríguez, 61 Rodríguez | | 14 Rodríguez, 42 Eto'o | | (4-4-2): Lehmann 7, Zambrotta 7, Heinze 8, Chivu 6½, Mexès 7½, Cambiasso 6½, Rodríguez 7½, Sneijder 7, Huntelaar 7, Eto'o 6, Ronaldinho 6 | | Cheltenham Town | 2 | 1 Güiza, 75 Silvestre | | Half-time: | 1-0 | | Referee: | Styles 6 | | Attendance: | 49,898 | | Possession: | 57%-43% | | Total shots: | 19-11 | | MoM: | Vidic |
| | 82 Silvestre | | (4-3-3): Friedel 7½, Diana 7½, Van Bronckhorst 7, Gilberto Silva 6 (48 Papadopoulos 7½), Dellas 7, Silvestre 7½, Govou 7½, Wendell 7, Güiza 6, Bellamy 6½ (74 Kádár 6), Makaay 6½ | | Blackpool | 0 |
| | 40 Vidic, 55 Raúl García | | (4-4-2): Júlio César 7, Richards 7½, Traoré 7½, De Rossi 7, Albiol 7, Vidic 8, Raúl García 6½ (66 Kightly 7), João Moutinho 6, Keirrison 7½, Agüero 6½, Arda 6½ | | Gillingham | 0 |
| | Half-time: | 0-0 | | Referee: | Dowd 7½ | | Attendance: | 44,244 | | Possession: | 47%-53% | | Total shots: | 19-17 | | MoM: | Dzeko |
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| | (4-4-2): Diego López 7½, Bosingwa 7, Westermann 7½, Puyol 7½, Ricardo Carvalho 6½, Mikel 6½, Valencia 7, Santi 6, Pandev 7½, Higuaín 6½, Anelka 6½ | | Huddersfield Town | 0 |
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| | (4-4-2): Malafeev 7½, Torosidis 7½, Schulz 6, Mavuba 6½, Amorebieta 7½, Garay 7, Iraola 7, Keita 7½, Dzeko 8, Biglia 7, Frei 6½ | | Liverpool | 3 | 3 Ronaldo, 63 Ferdinand, 86p Ronaldo | | Half-time: | 1-1 | | Referee: | D'Urso 7½ | | Attendance: | 72,438 | | Possession: | 60%-40% | | Total shots: | 32-4 | | MoM: | Chiellini | | TV: | live |
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| | (3-4-3): Reina 7½, Daniel 5½ (61 Acquafresca 7½), Chiellini 7½, Marchena 7, Ferdinand 7½, Felipe Melo 7, Ronaldo 7, Lampard 7, Henry 6½, Rooney 6½, Iniesta 7 | | Wrexham | 1 | 37 Gomez | | 39 Javi Martínez, 56 Gomez, 85 Godín | | (4-3-3): Cech 6½, Boateng 7, Lahm 6½, Demichelis 7 (66 Defour 6½), Godín 6½, Diarra 6½, Rakitic 7, Javi Martínez 7 (66 Witsel 6), Gomez 7, Gourcuff 7, Nasri 6½ | | Port Vale | 1 | 12 Bale | | Half-time: | 1-1 | | Referee: | Atkinson 6½ | | Attendance: | 34,326 | | Possession: | 49%-51% | | Total shots: | 10-14 | | MoM: | Messi |
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| | (1-3-3-3): Wiese 6, Zaccardo 6, Bale 6½, Essien 7, Rami 7, Fernando Meira 6, Maniche 6½ (78 Huddlestone 6), Simão 6½, Adebayor 6½, Källström 6½, McFadden 6 | | Arsenal | 2 | 15 Messi, 64 Messi | | 19 Lúcio | | (4-3-3): Buffon 7, Heitinga 6½, Córdoba 7, Flamini 7, Cannavaro 7, Lúcio 6, Kaká 7, Xabi Alonso 6½, Messi 7½, Van Nistelrooy 7, Van Persie 6 | | Stoke City | 1 | 15 Kuyt | | Half-time: | 1-0 | | Referee: | Beeby 6 | | Attendance: | 36,250 | | Possession: | 49%-51% | | Total shots: | 17-11 | | MoM: | Gattuso |
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| | (3-5-2): Coupet 7½, Squillaci 7, Armand 7½, Srna 8, Pienaar 6½, Lopo 7½, Rosický 7½, Taddei 7½, Kuyt 7, Demel 6, Quaresma 6½ | | Leeds United | 0 |
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| | (4-3-3): Eduardo 7, Fritz 8, Adriano 7, Gattuso 8, Samuel 6½ (64 Modric 6½), Van Buyten 6, Bystrov 7½, Rolfes 6, Berbatov 6½, De Jong 6, Shevchenko 7 | | Tottenham Hotspur | 0 |
| | Half-time: | 0-0 | | Referee: | Tanner 6½ | | Attendance: | 69,801 | | Possession: | 49%-51% | | Total shots: | 12-8 | | MoM: | Van Der Sar | | TV: | highlights |
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| | (4-4-2): Casillas 8, Anyukov 7½, Cole 7½, Agger 7½, Marquez 7, Fabregas 7½, Vílla 7½, Diego 7, Fernando Torres 6, Silva 7½, Ribéry 6½ | | Watford | 0 |
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| | (4-3-3): Van Der Sar 8, Bonnart 7, Distin 7, Vertonghen 7, Bordon 7, Brighi 6½ (66 Finnan 7), Osman 6, Rotan 7, Nuno Gomes 6½, Babel 6, Farfán 6½ |
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