| Round 21 | | Birmingham City | 0 |
| | Half-time: | 0-1 | | Referee: | Dowd 5 | | Attendance: | 35,417 | | Possession: | 39%-61% | | Total shots: | 5-19 | | MoM: | Carvajal | | TV: | highlights |
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| | (4-3-3): Karius 6, Hoogma 6½, Brunt 7½, Barry 7 (51 Badu 6), Tah 6, Burke 6, Carrick 6½, Musa 6½, Morris 6½, Long 5½, Choupo-Moting 6 | | Blackpool | 2 | 21 Iniesta, 67p Ronaldo |
| | (4-3-3): Leno 6, Carvajal 8½, Alex Sandro 8, Kanté 7½, Marquinhos 7, Höwedes 7, Hamsík 7½, Iniesta 7, Ronaldo 7½, Ibrahimovic 6½, Rodríguez 7½ | | Bury | 3 | 52 Çalhanoglu, 54 Immobile, 90+1 Immobile | | Half-time: | 0-0 | | Referee: | Foy 8 | | Attendance: | 48,404 | | Possession: | 47%-53% | | Total shots: | 12-11 | | MoM: | Rose |
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| | (4-4-2): Schmeichel 7, Simpson 7, Rose 8, Coquelin 7½, Roncaglia 7, Mathieu 7, Davis 6½, Gnabry 7½, Immobile 7, Çalhanoglu 6½, Vázquez 7 | | Bournemouth | 2 | 59 Gomez, 82 Hiljemark | | 1 Hiljemark, 36 Gomez, 50 Puel | | (4-3-3): Adrián 6, Shishkin 7, Ansaldi 6½, Darida 7½, Daniel Carrico 7, Nordtveit 6, Nasri 6½, Konoplyanka 7 (80 Colback 6½), Gomez 7, Hiljemark 6½, Puel 6 | | Cheltenham Town | 1 | 55 Aubameyang | | Half-time: | 0-0 | | Referee: | Styles 6½ | | Attendance: | 56,127 | | Possession: | 45%-55% | | Total shots: | 15-16 | | MoM: | De Gea |
| | 24 Aubameyang, 36 Umtiti | | (4-4-2): Oblak 7½, Filipe Luis 8, Abate 6½, El Shaarawy 6½, Vertonghen 7½, Umtiti 7, Douglas Costa 7½, Rakitic 7, Aubameyang 6½, De Bruyne 7, Mkhitaryan 7 | | Wrexham | 0 |
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| | (4-3-3): De Gea 8, Bellerín 6, Romagnoli 6½ (66 Matuidi 7), Boateng 7½, Otamendi 6½, Kroos 7, Koke 6½, Verratti 6, Kane 6, Saúl 6½, Neymar 6½ | | Gillingham | 1 | 67 Bale | | Half-time: | 0-0 | | Referee: | Rennie 6 | | Attendance: | 61,451 | | Possession: | 50%-50% | | Total shots: | 16-17 | | MoM: | Thiago Silva | | TV: | live |
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| | (4-3-3): Forster 7, Smalling 6½, Delph 7, Ramsey 7, Cahill 7, Dier 6, Wilson 6, Bale 7, Wilson 6, Welbeck 6, Rooney 7½ | | Liverpool | 1 | 77 Messi |
| | (4-1-3-2): Neuer 7, Dani Alves 7½, Kurzawa 7½, Mascherano 7½, Thiago Silva 8, David Luiz 7, Pogba 6½, Müller 6½, Lewandowski 6½, Messi 7½, Pedro 6½ | | Ipswich Town | 3 | 11 Giroud, 31 Giroud, 77 Insigne | | Half-time: | 2-2 | | Referee: | D'Urso 7½ | | Attendance: | 48,153 | | Possession: | 44%-56% | | Total shots: | 15-18 | | MoM: | Jonny |
| | 41 Imbula | | (4-5-1): Perin 6½, Rosales 7½, Jonny 7½, João Moutinho 7, Astori 7½, Moreno 7, Mahrez 6½, Kagawa 7½, Giroud 5½ (68 Jonas 7), Imbula 6½, Insigne 6½ | | Crystal Palace | 2 | 15 Cuadrado, 26 Yarmolenko | | 82 Clichy | | (4-3-3): Casillas 6, Clichy 6½, Yanga-Mbiwa 7, Sergi Gómez 7, De Sciglio 7½, Sturaro 6, Tolisso 7, Yarmolenko 7, Bernardo Silva 6½, Cuadrado 6, Werner 6 | | Manchester United | 0 |
| | Half-time: | 0-2 | | Referee: | Wiley 7 | | Attendance: | 49,920 | | Possession: | 44%-56% | | Total shots: | 8-20 | | MoM: | Henderson | | TV: | highlights |
| | 43 Bonaventura | | (3-3-3-1): Tatarusanu 6½, Nacho Monreal 7, Van Der Wiel 7, Can 7½, Bocchetti 6, Tomovic 6½, Aleix Vidal 7, Salah 7 (73 Menez 6½), Ziyech 7 (66 Vecino 5½), Bonaventura 5½, Bacca 7 | | Tottenham Hotspur | 2 | 16 Asamoah, 21 Sterling |
| | (4-4-2): Foster 7, Walker 7, Davies 6½, Henderson 8, Stones 6½, Alli 7, Drinkwater 6½, Lallana 6, Vardy 6½, Sterling 7, Asamoah 8 | | Port Vale | 2 | 19 Phillips, 48 Phillips | | Half-time: | 1-1 | | Referee: | Walton 6½ | | Attendance: | 33,129 | | Possession: | 55%-45% | | Total shots: | 17-10 | | MoM: | Horta | | TV: | highlights |
| | 33 Gameiro, 80 Sigurðsson, 84 Chadli | | (4-4-2): Sommer 6, Arias 7½, Bertrand 6½, Casemiro 7, José Fonte 7½, Rami 6½, Horta 7½, Phillips 7, Gameiro 7½, Sigurðsson 7½, Chadli 6 (86 Ritchie 6) | | Burnley | 3 | 8 Pastore, 64 Martínez, 86 Pastore | | 36 Joselu | | (4-3-3): Volkan 6, Lowton 7, Funes Mori 6½, Rode 6½, Maicon 7, Dawson 6, Pérez 7, Pastore 7½, Martínez 6½, Joselu 6, Bojan 7 (47 John 6) | | Portsmouth | 7 | 20 Sansone, 36 Lukaku, 44 Lukaku, 51 Di María, 55 Lukaku, 73 Sansone, 80 Di María | | Half-time: | 3-0 | | Referee: | Webb 7 | | Attendance: | 36,354 | | Possession: | 50%-50% | | Total shots: | 20-12 | | MoM: | Di María |
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| | (4-4-2): Szczesny 7, Laporte 7, Gündogan 7, Herrera 6½, Kimmich 7½, Juan 6½, Di María 7½, Reus 7, Sansone 6½, Bernat 7, Lukaku 6½ | | Newcastle United | 0 |
| | 70 Philippe Coutinho | | (3-4-3): Mandanda 7, Juanfran 7½, Azpilicueta 6½, Fernando 6½, Rodríguez 6½, Callejón 6½, Schürrle 7, Dani Ceballos 6, Higuaín 7, Coman 6, Philippe Coutinho 5½ | | Shrewsbury Town | 3 | 11 Payet, 67 Griezmann, 76 Payet | | Half-time: | 1-0 | | Referee: | Marriner 5½ | | Attendance: | 38,980 | | Possession: | 47%-53% | | Total shots: | 15-8 | | MoM: | Schmelzer |
| | 33 Fekir | | (4-3-3): Lloris 7½, Sidibé 7, Schmelzer 8, Van Dijk 7, Süle 7, Kramer 7, Payet 7½, Gonalons 6½, Lacazette 7, Fekir 5½ (81 Veltman 6), Griezmann 7 | | Chester | 0 |
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| | (4-3-3): Diego 7, Sergi Roberto 7, Radu 7, Biglia 7½, Miranda 6, Gabriel Paulista 6, Zivkovic 7, Ocampos 6½ (84 Adrián Marín 6), Batshuayi 6½, Mehmet 6½, Rémy 6 | | Round 22 | | Birmingham City | 0 |
| | Half-time: | 0-1 | | Referee: | Hill 7 | | Attendance: | 25,343 | | Possession: | 50%-50% | | Total shots: | 15-14 | | MoM: | Tah |
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| | (4-3-3): Karius 6½, Hoogma 6½, Brunt 7, Barry 7 (51 Badu 8), Tah 8½, Burke 5½, Carrick 7, Musa 7, Morris 6, Long 6½, Choupo-Moting 6½ | | Manchester United | 1 | 2 Bacca |
| | (3-3-3-1): Tatarusanu 7½, Nacho Monreal 7, Van Der Wiel 7, Can 6½, Bocchetti 8, Tomovic 7, Aleix Vidal 7, Salah 8, Ziyech 5½, Bonaventura 7½, Bacca 7 | | Blackpool | 3 | 3 Ronaldo, 24 Hamsík, 59 Ronaldo | | Half-time: | 2-0 | | Referee: | Taylor 6½ | | Attendance: | 70,209 | | Possession: | 62%-38% | | Total shots: | 16-7 | | MoM: | Marquinhos |
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| | (4-3-3): Leno 7, Carvajal 7, Alex Sandro 7, Kanté 7, Marquinhos 8, Höwedes 7, Hamsík 8, Iniesta 6, Ronaldo 7, Ibrahimovic 7, Rodríguez 6½ | | Cheltenham Town | 0 |
| | 12 Umtiti, 23 Mkhitaryan, 32 Rakitic | | (4-4-2): Oblak 7, Filipe Luis 7, Abate 6, El Shaarawy 7, Vertonghen 6½, Umtiti 6½, Douglas Costa 6½, Rakitic 6, Aubameyang 7, De Bruyne 6½, Mkhitaryan 6 | | Bournemouth | 1 | 77 Gomez | | Half-time: | 0-2 | | Referee: | Hall 7 | | Attendance: | 36,244 | | Possession: | 39%-61% | | Total shots: | 11-14 | | MoM: | Darida |
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| | (4-3-3): Adrián 5½, Shishkin 6½ (84 Dowell 6), Ansaldi 7, Darida 7½, Mammana 6, Daniel Carrico 6, Nasri 6½, Konoplyanka 6, Gomez 7, Hiljemark 7½, Puel 5½ | | Arsenal | 3 | 11 Isco, 36 Isco, 90+2 Isco |
| | (5-3-2): Trapp 6, Jordi Alba 7½, Giménez 6, Piqué 6, Karsdorp 7½, Busquets 7½, Xabi Alonso 6½, Isco 7½, Özil 7½, Cavani 7, Diego Costa 6½ | | Burnley | 1 | 18 Pastore | | Half-time: | 1-0 | | Referee: | Troupkos 6½ | | Attendance: | 39,099 | | Possession: | 51%-49% | | Total shots: | 14-10 | | MoM: | Lloris |
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| | (4-3-3): Volkan 7½, Lowton 6, Funes Mori 6, Rode 7½, Maicon 6, Dawson 6½, Pérez 7½, Pastore 7, Martínez 7, Joselu 6½ (70 Rosický 6½), Bojan 7 | | Shrewsbury Town | 0 |
| | 35 Süle | | (4-3-3): Lloris 8, Sidibé 7½, Schmelzer 7 (66 Mendy 8), Van Dijk 8, Süle 6, Kramer 6½ (66 Younes 7½), Payet 6½, Gonalons 6½, Lacazette 7, Fekir 6, Griezmann 7 | | Chester | 1 | 14 Biglia | | Half-time: | 1-1 | | Referee: | Stamatopoulos 8½ | | Attendance: | 19,888 | | Possession: | 43%-57% | | Total shots: | 7-14 | | MoM: | Hazard |
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| | (4-3-3): Diego 6½, Sergi Roberto 7, Radu 6½, Biglia 6, Miranda 6½, Gabriel Paulista 6, Zivkovic 6, Ocampos 6½ (77 Adrián Marín 6½), Batshuayi 7, Mehmet 7½, Rémy 6 | | Swansea City | 1 | 10 Rashford |
| | (4-1-3-2): Rui Patrício 8, Zappacosta 7, Marcelo 8, Alaba 8, Hummels 7½, Musacchio 7, Modric 7, Hazard 8, Silva 7, Rashford 6½, Benzema 7½ | | Crystal Palace | 3 | 26 Clichy, 29 Yarmolenko, 52 Cuadrado | | Half-time: | 2-1 | | Referee: | Shoebridge 6½ | | Attendance: | 41,213 | | Possession: | 48%-52% | | Total shots: | 15-7 | | MoM: | Clichy |
| | 56 Sergi Gómez | | (4-3-3): Casillas 7, Clichy 7½, Yanga-Mbiwa 6, Sergi Gómez 7, De Sciglio 6½, Sturaro 6½, Tolisso 6½, Yarmolenko 6, Bernardo Silva 6½, Cuadrado 7, Werner 6½ | | Port Vale | 1 | 11 Chadli | | 42 Gameiro, 83 Bertrand | | (4-4-2): Sommer 7, Arias 6, Bertrand 7, Casemiro 6½, José Fonte 7, Rami 6½, Horta 7, Phillips 7, Gameiro 7, Sigurðsson 6½, Chadli 6½ (81 Ritchie 6) | | Ipswich Town | 1 | 50 Insigne | | Half-time: | 0-1 | | Referee: | Salisbury 7 | | Attendance: | 60,424 | | Possession: | 38%-62% | | Total shots: | 13-23 | | MoM: | Rosales |
| | 35 Imbula | | (4-5-1): Perin 4½, Rosales 8, Jonny 7, João Moutinho 7½, Astori 6½, Moreno 6½, Mahrez 6, Kagawa 6, Giroud 6½ (68 Jonas 7), Imbula 5½, Insigne 7 | | Liverpool | 4 | 34 Müller, 47 Lewandowski, 55 David Luiz, 59 Pedro |
| | (4-1-3-2): Neuer 5½, Dani Alves 7½, Kurzawa 6½, Mascherano 7½, Thiago Silva 7, David Luiz 6½ (76 Matic 6), Pogba 7 (76 Vitolo 6), Müller 6½, Lewandowski 7½, Messi 7, Pedro 7½ | | Newcastle United | 2 | 5 Higuaín, 16 Higuaín | | Half-time: | 2-0 | | Referee: | Foster 5½ | | Attendance: | 56,356 | | Possession: | 59%-41% | | Total shots: | 19-10 | | MoM: | Juanfran |
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| | (3-4-3): Mandanda 7, Juanfran 8, Azpilicueta 7, Fernando 7½, Rodríguez 7, Callejón 7, Schürrle 7, Dani Ceballos 7½, Higuaín 7½, Coman 7, Philippe Coutinho 6 | | Bury | 0 |
| | 67 Vázquez, 80 Roncaglia | | (4-4-2): Schmeichel 7, Simpson 7, Rose 7, Coquelin 7, Roncaglia 6, Mathieu 6½, Davis 7½, Gnabry 6½, Immobile 7 (81 Víetto 6), Çalhanoglu 6, Vázquez 7 (76 Tello 6) |
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